ENSMUSG00000007564


Mus musculus

Features
Gene ID: ENSMUSG00000007564
  
Biological name :Ppp2r1a
  
Synonyms : Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / Q76MZ3
  
Possible biological names infered from orthology : P30153 / protein phosphatase 2 scaffold subunit Aalpha
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.2
Gene start: 20945311
Gene end: 20965916
  
Corresponding Affymetrix probe sets: 10442155 (MoGene1.0st)   1415819_a_at (Mouse Genome 430 2.0 Array)   1438174_x_at (Mouse Genome 430 2.0 Array)   1438383_x_at (Mouse Genome 430 2.0 Array)   1438991_x_at (Mouse Genome 430 2.0 Array)   1455929_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133778
Ensembl peptide - ENSMUSP00000007708
Ensembl peptide - ENSMUSP00000133334
NCBI entrez gene - 51792     See in Manteia.
MGI - MGI:1926334
RefSeq - NM_016891
RefSeq Peptide - NP_058587
swissprot - Q76MZ3
swissprot - G3UWL2
swissprot - G3UXQ1
Ensembl - ENSMUSG00000007564
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P30153ENSG00000105568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TNP2 / Ppp2r1b / protein phosphatase 2, regulatory subunit A, beta / P30154* / protein phosphatase 2 scaffold subunit Abeta*ENSMUSG0000003205886


Protein motifs (from Interpro)
Interpro ID Name
 IPR000357  HEAT repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR031090  Serine/threonine-protein phosphatase 2A subunit A, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0051232 meiotic spindle elongation IMP
 biological_processGO:0051306 mitotic sister chromatid separation IMP
 biological_processGO:0051754 meiotic sister chromatid cohesion, centromeric IMP
 biological_processGO:0070262 peptidyl-serine dephosphorylation IDA
 biological_processGO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:1990405 protein antigen binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic Background: FVB.129S1-Ppp2r1atm1.2Wltr

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic Background: FVB.129S1-Ppp2r1atm1.2Wltr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic Background: FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr

Allelic Composition: Ppp2r1atm2.1Wltr/Ppp2r1atm2.1Wltr
Genetic Background: FVB.129-Ppp2r1atm2.1Wltr

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic Background: FVB.129S1-Ppp2r1atm1.2Wltr

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic Background: FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic Background: FVB.129S1-Ppp2r1atm1.2Wltr

Allelic Composition: Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic Background: FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / complex
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction
 ENSMUSG00000026626 Q6PD03 / Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q15172* / protein phosphatase 2 regulatory subunit Balpha*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000022052 Q6P1F6 / Ppp2r2a / protein phosphatase 2, regulatory subunit B, alpha / P63151* / protein phosphatase 2 regulatory subunit Balpha*  / complex






 

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