ENSMUSG00000032058


Mus musculus

Features
Gene ID: ENSMUSG00000032058
  
Biological name :Ppp2r1b
  
Synonyms : Ppp2r1b / protein phosphatase 2, regulatory subunit A, beta / Q7TNP2
  
Possible biological names infered from orthology : P30154 / protein phosphatase 2 scaffold subunit Abeta
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 50845301
Gene end: 50894229
  
Corresponding Affymetrix probe sets: 10585249 (MoGene1.0st)   1428265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135871
Ensembl peptide - ENSMUSP00000034560
Ensembl peptide - ENSMUSP00000110080
Ensembl peptide - ENSMUSP00000133404
Ensembl peptide - ENSMUSP00000134740
Ensembl peptide - ENSMUSP00000134886
Ensembl peptide - ENSMUSP00000135253
Ensembl peptide - ENSMUSP00000135525
Ensembl peptide - ENSMUSP00000135758
NCBI entrez gene - 73699     See in Manteia.
MGI - MGI:1920949
RefSeq - XM_006510642
RefSeq - NM_001034085
RefSeq - NM_001286553
RefSeq - NM_028614
RefSeq - XM_006510641
RefSeq Peptide - NP_001273482
RefSeq Peptide - NP_082890
RefSeq Peptide - NP_001029257
swissprot - Q7TNP2
swissprot - G3UWS4
swissprot - H3BJ83
swissprot - H3BK50
swissprot - H3BKU1
swissprot - H3BLQ0
swissprot - H3BLE7
swissprot - H3BIV7
swissprot - Q3TTF6
Ensembl - ENSMUSG00000032058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r1baENSDARG00000007791Danio rerio
 ppp2r1bbENSDARG00000032430Danio rerio
 P30154ENSG00000137713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*ENSMUSG0000000756473


Protein motifs (from Interpro)
Interpro ID Name
 IPR000357  HEAT repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060561 apoptotic process involved in morphogenesis ISO
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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contact: otassy@igbmc.fr