ENSG00000137713


Homo sapiens

Features
Gene ID: ENSG00000137713
  
Biological name :PPP2R1B
  
Synonyms : P30154 / PPP2R1B / protein phosphatase 2 scaffold subunit Abeta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.1
Gene start: 111726908
Gene end: 111766427
  
Corresponding Affymetrix probe sets: 202883_s_at (Human Genome U133 Plus 2.0 Array)   202884_s_at (Human Genome U133 Plus 2.0 Array)   202885_s_at (Human Genome U133 Plus 2.0 Array)   202886_s_at (Human Genome U133 Plus 2.0 Array)   222351_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433598
Ensembl peptide - ENSP00000432666
Ensembl peptide - ENSP00000434705
Ensembl peptide - ENSP00000437193
Ensembl peptide - ENSP00000436626
Ensembl peptide - ENSP00000311344
Ensembl peptide - ENSP00000343317
Ensembl peptide - ENSP00000376775
Ensembl peptide - ENSP00000410671
NCBI entrez gene - 5519     See in Manteia.
OMIM - 603113
RefSeq - XM_017017961
RefSeq - NM_001177562
RefSeq - NM_001177563
RefSeq - NM_002716
RefSeq - NM_181699
RefSeq - NM_181700
RefSeq - XM_017017958
RefSeq - XM_017017959
RefSeq - XM_017017960
RefSeq Peptide - NP_001171033
RefSeq Peptide - NP_001171034
RefSeq Peptide - NP_002707
RefSeq Peptide - NP_859050
RefSeq Peptide - NP_859051
swissprot - E9PHZ6
swissprot - P30154
swissprot - E9PPI5
swissprot - E9PNM7
swissprot - H0YDG7
Ensembl - ENSG00000137713
  
Related genetic diseases (OMIM): 211980 - Lung cancer, 211980
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r1baENSDARG00000007791Danio rerio
 ppp2r1bbENSDARG00000032430Danio rerio
 Q7TNP2ENSMUSG00000032058Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit AalphaENSG0000010556875


Protein motifs (from Interpro)
Interpro ID Name
 IPR000357  HEAT repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060561 apoptotic process involved in morphogenesis IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0006519 Alveolar cell carcinoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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