Manteia

ENSMUSG00000009630

Mus musculus

Features

Gene ID:	ENSMUSG00000009630

Biological name :	Ppp2cb

Synonyms :	P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Possible biological names infered from orthology :	P62714 / protein phosphatase 2 catalytic subunit beta

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	A3
Gene start:	33599625
Gene end:	33619441

Corresponding Affymetrix probe sets:	10571266 (MoGene1.0st) 1421822_at (Mouse Genome 430 2.0 Array) 1421823_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000009774 NCBI entrez gene - 19053 See in Manteia. MGI - MGI:1321161 RefSeq - NM_017374 RefSeq - XM_006509033 RefSeq Peptide - NP_059070 swissprot - P62715 Ensembl - ENSMUSG00000009630

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*	ENSMUSG00000020349	97
Ppp4c / P97470 / protein phosphatase 4, catalytic subunit / P60510*	ENSMUSG00000030697	64

Protein motifs (from Interpro)

Interpro ID	Name
IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052	Metallo-dependent phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0008637	apoptotic mitochondrial changes	IMP
biological_process	GO:0010288	response to lead ion	IEA
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0034976	response to endoplasmic reticulum stress	IMP
biological_process	GO:0042542	response to hydrogen peroxide	IMP
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0046580	negative regulation of Ras protein signal transduction	IEA
biological_process	GO:0046677	response to antibiotic	IMP
biological_process	GO:1904528	positive regulation of microtubule binding	IEA
cellular_component	GO:0000159	protein phosphatase type 2A complex	IDA
cellular_component	GO:0000775	chromosome, centromeric region	IEA
cellular_component	GO:0000922	spindle pole	IEA
cellular_component	GO:0005634	nucleus	TAS
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004722	protein serine/threonine phosphatase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008022	protein C-terminus binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp2ca^tm1.2Nju/Ppp2ca^tm1.2Nju Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000034342	Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*	/ reaction
ENSMUSG00000007564	Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*	/ complex
ENSMUSG00000022114	Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*	/ complex
ENSMUSG00000006932	Ctnnb1 / Q02248 / Catenin beta-1 / P35222*	/ reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ reaction / complex
ENSMUSG00000027646	Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*	/ reaction
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ reaction
ENSMUSG00000026626	Q6PD03 / Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q15172* / protein phosphatase 2 regulatory subunit Balpha*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr