ENSMUSG00000030697


Mus musculus

Features
Gene ID: ENSMUSG00000030697
  
Biological name :Ppp4c
  
Synonyms : P97470 / Ppp4c / protein phosphatase 4, catalytic subunit
  
Possible biological names infered from orthology : P60510
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126785866
Gene end: 126792496
  
Corresponding Affymetrix probe sets: 10568040 (MoGene1.0st)   1445350_at (Mouse Genome 430 2.0 Array)   1460288_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146013
Ensembl peptide - ENSMUSP00000146245
Ensembl peptide - ENSMUSP00000146240
Ensembl peptide - ENSMUSP00000146202
Ensembl peptide - ENSMUSP00000146180
Ensembl peptide - ENSMUSP00000146088
Ensembl peptide - ENSMUSP00000032936
NCBI entrez gene - 56420     See in Manteia.
MGI - MGI:1891763
RefSeq - XM_006508049
RefSeq - NM_019674
RefSeq Peptide - NP_062648
swissprot - A0A0U1RPK2
swissprot - A0A0U1RQ12
swissprot - A0A0U1RQ43
swissprot - P97470
swissprot - Q3UNF2
swissprot - A0A0U1RPR5
swissprot - A0A0U1RPZ1
Ensembl - ENSMUSG00000030697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A8WGP3ENSDARG00000070570Danio rerio
 A9JRC7ENSDARG00000076439Danio rerio
 PPP4CENSG00000149923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*ENSMUSG0000000963065
P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*ENSMUSG0000002034965


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030289 protein phosphatase 4 complex IDA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity NAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ppp4ctm1Tht/Ppp4ctm1Tht,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ppp4ctm1Tht/Ppp4ctm1Tht,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ppp4ctm1Tht/Ppp4ctm1Tht,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ppp4ctm1Tht/Ppp4ctm1Tht,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction
 ENSMUSG00000052144 Ppp4r2 / protein phosphatase 4 regulatory subunit 2 / Q9NY27*  / complex






 

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