ENSG00000149923


Homo sapiens

Features
Gene ID: ENSG00000149923
  
Biological name :PPP4C
  
Synonyms : P60510 / PPP4C / protein phosphatase 4 catalytic subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 30075978
Gene end: 30085377
  
Corresponding Affymetrix probe sets: 208932_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461609
Ensembl peptide - ENSP00000458079
Ensembl peptide - ENSP00000486140
Ensembl peptide - ENSP00000279387
Ensembl peptide - ENSP00000455394
Ensembl peptide - ENSP00000455995
Ensembl peptide - ENSP00000457089
Ensembl peptide - ENSP00000457915
NCBI entrez gene - 5531     See in Manteia.
OMIM - 602035
RefSeq - XM_017023404
RefSeq - NM_001303503
RefSeq - NM_001303504
RefSeq - NM_001303506
RefSeq - NM_001303507
RefSeq - NM_002720
RefSeq - XM_006721061
RefSeq - XM_017023403
RefSeq Peptide - NP_002711
RefSeq Peptide - NP_001290432
RefSeq Peptide - NP_001290433
RefSeq Peptide - NP_001290435
RefSeq Peptide - NP_001290436
swissprot - H3BPN5
swissprot - H3BTA2
swissprot - H3BV22
swissprot - P60510
swissprot - A0A024R625
swissprot - H3BVE3
swissprot - I3L4X0
Ensembl - ENSG00000149923
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A8WGP3ENSDARG00000070570Danio rerio
 A9JRC7ENSDARG00000076439Danio rerio
 Ppp4cENSMUSG00000030697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62714 / PPP2CB / protein phosphatase 2 catalytic subunit betaENSG0000010469565
P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alphaENSG0000011357565


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IMP
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030289 protein phosphatase 4 complex IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity NAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000163605 PPP4R2 / Q9NY27 / protein phosphatase 4 regulatory subunit 2  / complex






 

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