ENSMUSG00000052144


Mus musculus

Features
Gene ID: ENSMUSG00000052144
  
Biological name :Ppp4r2
  
Synonyms : Ppp4r2 / protein phosphatase 4 regulatory subunit 2
  
Possible biological names infered from orthology : Q9NY27
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D3
Gene start: 100833622
Gene end: 100869934
  
Corresponding Affymetrix probe sets: 10540283 (MoGene1.0st)   10608685 (MoGene1.0st)   1433850_at (Mouse Genome 430 2.0 Array)   1433851_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066314
Ensembl peptide - ENSMUSP00000145102
Ensembl peptide - ENSMUSP00000144898
NCBI entrez gene - 232314     See in Manteia.
MGI - MGI:3027896
RefSeq - NM_182939
RefSeq - XM_006506008
RefSeq Peptide - NP_891984
swissprot - A0A0N4SVH3
swissprot - A0A0N4SV05
swissprot - A0A0R4J0U2
Ensembl - ENSMUSG00000052144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1L1M4ENSDARG00000053447Danio rerio
 ppp4r2aENSDARG00000026540Danio rerio
 PPP4R2ENSGALG00000007810Gallus gallus
 PPP4R2ENSG00000163605Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015267  Protein phosphatase 4 core regulatory subunit R2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0030289 protein phosphatase 4 complex IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0005387 immune system phenotype 
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0013511 increased CD4-negative NK T cell number "increase in the number of CD4-negative NK T cells" [MGI:Saran]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0013513 decreased memory-marker CD4-negative NK T cell number "reduction in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030697 Ppp4c / P97470 / protein phosphatase 4, catalytic subunit / P60510*  / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction






 

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