ENSMUSG00000020349


Mus musculus

Features
Gene ID: ENSMUSG00000020349
  
Biological name :Ppp2ca
  
Synonyms : P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
  
Possible biological names infered from orthology : P67775 / protein phosphatase 2 catalytic subunit alpha
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 52098681
Gene end: 52127778
  
Corresponding Affymetrix probe sets: 10375926 (MoGene1.0st)   1417367_at (Mouse Genome 430 2.0 Array)   1439912_at (Mouse Genome 430 2.0 Array)   1456390_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020608
NCBI entrez gene - 19052     See in Manteia.
MGI - MGI:1321159
RefSeq - NM_019411
RefSeq Peptide - NP_062284
swissprot - P63330
Ensembl - ENSMUSG00000020349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP2CAENSDARG00000053404Danio rerio
 PPP2CAENSGALG00000006462Gallus gallus
 P67775ENSG00000113575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*ENSMUSG0000000963097
Ppp4c / P97470 / protein phosphatase 4, catalytic subunit / P60510*ENSMUSG0000003069764


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation ISO
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0010469 regulation of signaling receptor activity ISO
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0031952 regulation of protein autophosphorylation ISO
 biological_processGO:0042176 regulation of protein catabolic process ISO
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0070208 protein heterotrimerization ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity ISO
 molecular_functionGO:0050811 GABA receptor binding IDA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpx3tm1Jlos/Gpx3+
Genetic Background: B6N.Cg-Gpx3tm1Jlos

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
Show

Allelic Composition: Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan,Tg(Thy1-MAPT)5Vln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000022052 Q6P1F6 / Ppp2r2a / protein phosphatase 2, regulatory subunit B, alpha / P63151* / protein phosphatase 2 regulatory subunit Balpha*  / complex
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / complex
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction






 

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