ENSMUSG00000002413


Mus musculus

Features
Gene ID: ENSMUSG00000002413
  
Biological name :Braf
  
Synonyms : Braf / P28028 / Serine/threonine-protein kinase B-raf
  
Possible biological names infered from orthology : B-Raf proto-oncogene, serine/threonine kinase / P15056
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 39603237
Gene end: 39725463
  
Corresponding Affymetrix probe sets: 10544219 (MoGene1.0st)   1425693_at (Mouse Genome 430 2.0 Array)   1435434_at (Mouse Genome 430 2.0 Array)   1435480_at (Mouse Genome 430 2.0 Array)   1442749_at (Mouse Genome 430 2.0 Array)   1445786_at (Mouse Genome 430 2.0 Array)   1447940_a_at (Mouse Genome 430 2.0 Array)   1447941_x_at (Mouse Genome 430 2.0 Array)   1456505_at (Mouse Genome 430 2.0 Array)   1458641_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002487
Ensembl peptide - ENSMUSP00000099036
NCBI entrez gene - 109880     See in Manteia.
MGI - MGI:88190
RefSeq - XM_011241140
RefSeq - NM_139294
RefSeq - XM_011241137
RefSeq - XM_011241138
RefSeq - XM_011241139
RefSeq - XM_006505353
RefSeq - XM_006505355
RefSeq - XM_006505358
RefSeq - XM_006505359
RefSeq - XM_011241134
RefSeq - XM_011241135
RefSeq - XM_011241136
RefSeq Peptide - NP_647455
swissprot - P28028
swissprot - F6SZ47
Ensembl - ENSMUSG00000002413
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brafENSDARG00000017661Danio rerio
 BRAFENSGALG00000012865Gallus gallus
 BRAFENSG00000157764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*ENSMUSG0000000044145
Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000112744
Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*ENSMUSG0000001833423
Ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSMUSG0000006157822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002318 myeloid progenitor cell differentiation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010764 negative regulation of fibroblast migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043368 positive T cell selection IMP
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045580 regulation of T cell differentiation IMP
 biological_processGO:0046632 alpha-beta T cell differentiation IMP
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0048679 regulation of axon regeneration IGI
 biological_processGO:0048680 positive regulation of axon regeneration IDA
 biological_processGO:0050772 positive regulation of axonogenesis IMP
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060323 head morphogenesis IMP
 biological_processGO:0060324 face development IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071277 cellular response to calcium ion ISO
 biological_processGO:0090150 establishment of protein localization to membrane ISO
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000301 negative regulation of synaptic vesicle exocytosis IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
CREB phosphorylation through the activation of Ras
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crhr1tm2.3Jde/Crhr1tm2.3Jde
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cd79atm1(BAP31N-EGFP)Pld/Cd79atm1(BAP31N-EGFP)Pld
Genetic Background: Not Specified

Allelic Composition: Braftm1Rima/Braf+,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Cd79atm1(BAP31N-EGFP)Pld/Cd79atm1(BAP31N-EGFP)Pld
Genetic Background: Not Specified

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001272 increased metastatic potential 
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0,Trp53tm2Tyj/Trp53tm2Tyj
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Rdp/Ptentm1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Mettm4Gvw/Met+
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm2.2Urr/Braftm2.2Urr
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001711 abnormal placenta 
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Braftm1Rima/Braf+,Krastm4Tyj/Kras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Mmcm/Braf+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Pcdh15m3Btlr/Pcdh15m3Btlr
Genetic Background: C57BL/6J-Pcdh15m3Btlr

Allelic Composition: Braftm1.1Brd/Braf+,Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Mmcm/Braf+,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Cpri/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm2Cpri/Braf+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Braftm1Mmcm/Braf+,Trp53tm3.1Tyj/Trp53+,Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2Cpri/Braf+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Wds/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm2Urr/Braftm2Urr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Braftm1.1Brd/Braf+,Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt12tm1.1(KRT12*L132P)Arte/Krt12tm1.1(KRT12*L132P)Arte
Genetic Background: involves: C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Pten+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Zbtb7atm1Ppp/Zbtb7atm2Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Braftm1.1Wds/Braftm1.1Wds
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Braftm1Wds/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0003968 abnormal growth hormone level 
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7atm1Ppp/Zbtb7atm2Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Braftm1.1Wds/Braftm1.1Wds
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Braftm2.2Urr/Braftm2.2Urr
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2.2Urr/Braftm2.2Urr
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0005577 uterine prolapse "downward movement, and possible external appearance, of the uterus through the vagina" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88284]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0005655 increased aggression "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005665 increased circulating noradrenaline level "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Zim/Braftm1Zim
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Mmcm/Braf+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Cpri/Braf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0008285 abnormal hippocampus granule cell layer 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0009386 abnormal dermal melanocyte morphology "any structural anomaly of the cells that produce pigment in the dermis" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009535 abnormal skin sebaceous gland morphology "any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Ighg1tm1(cre)Cgn/Ighg1+,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0009957 abnormal cerebellum vermis lobule morphology "any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688]
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0009988 abnormal cerebellum vermis lobule I morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009989 abnormal cerebellum vermis lobule II morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009990 abnormal cerebellum vermis lobule III morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009993 abnormal cerebellum vermis lobule V morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009995 abnormal cerebellum vermis lobule VII morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009997 abnormal cerebellum vermis lobule X morphology 
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Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010029 abnormal basicranium morphology "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

 MP:0010275 increased melanoma incidence "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd79atm1(BAP31N-EGFP)Pld/Cd79atm1(BAP31N-EGFP)Pld
Genetic Background: Not Specified

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

Allelic Composition: Braftm1Rima/Braf+,Tg(GFP/KRAS2/ALPP)1Brn/0,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Braftm1Tuv/Braftm1Tuv,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010288 increased gland tumor incidence "greater than the expected number of tumors originating in a gland in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1(BAP31N-EGFP)Pld/Cd79atm1(BAP31N-EGFP)Pld
Genetic Background: Not Specified

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Rdp/Ptentm1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Pten+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

 MP:0010346 increased thyroid carcinioma incidence "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * FVB/NCr

Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Braftm1Mmcm/Braf+,Trp53tm3.1Tyj/Trp53+,Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Allelic Composition: Braftm1Mmcm/Braf+,Trp53tm1Brn/Trp53tm3.1Tyj,Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Allelic Composition: Braftm1Mmcm/Braf+,Tg(TPO-cre/ERT2)1139Tyj/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010583 abnormal conotruncus morphology "any structural anomaly of the distal portion of the bulbus cordis that will give rise to the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010602 abnormal pulmonary valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010618 enlarged mitral valve "an increase in the total area occupied by the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010627 enlarged tricuspid valve "an increase in the total area occupied by the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010629 thick tricuspid valve 
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0,Trp53tm2Tyj/Trp53tm2Tyj
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm2Cpri/Braf+,Tg(CMV-cre)1Cgn/0
Genetic Background: B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Braftm1Zim/Braftm1Zim
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1.1Wds/Braftm1.1Wds
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm2.2Urr/Braftm2.2Urr
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Braftm1Zim/Braftm1Zim
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Cd79atm1(BAP31N-EGFP)Pld/Cd79atm1(BAP31N-EGFP)Pld
Genetic Background: Not Specified

Allelic Composition: Braftm2Cpri/Braf+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
Show

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Braftm2Urr/Braftm2Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0013957 increased small intestine length "increased length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
Show

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0013959 increased large intestine length "increased length of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal" [ISBN:0683400088]
Show

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0014081 branched small intestinal villi "atypical formation of branched tree-like structures in the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; branching may occur in association with increased or ectopic epithelial proliferation" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Braftm1.1Brd/Braf+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0020393 increased neuronal precursor proliferation "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Braftm2.1Urr/Braftm2.1Urr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0030245 round head "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna]
Show

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Braftm1Bbd/Braf+
Genetic Background: B6.129-Braftm1Bbd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000001127 Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / reaction / complex
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / complex / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / complex
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / reaction / complex
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / reaction / complex
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / reaction / complex
 ENSMUSG00000022114 Spry2 / Q9QXV8 / sprouty RTK signaling antagonist 2 / O43597*  / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000032959 Pebp1 / P70296 / phosphatidylethanolamine binding protein 1 / P30086*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000055725 Paqr3 / Q6TCG8 / progestin and adipoQ receptor family member III / Q6TCH7* / progestin and adipoQ receptor family member 3*  / reaction / complex
 ENSMUSG00000047104 Pbp2 / PEBP1* / P30086* / phosphatidylethanolamine binding protein 1*  / reaction / complex






 

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