ENSMUSG00000000441


Mus musculus

Features
Gene ID: ENSMUSG00000000441
  
Biological name :Raf1
  
Synonyms : Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / Q99N57 / Raf1
  
Possible biological names infered from orthology : P04049 / Raf-1 proto-oncogene, serine/threonine kinase
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E3
Gene start: 115618067
Gene end: 115676635
  
Corresponding Affymetrix probe sets: 10547034 (MoGene1.0st)   1416078_s_at (Mouse Genome 430 2.0 Array)   1425419_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144937
Ensembl peptide - ENSMUSP00000145520
Ensembl peptide - ENSMUSP00000000451
Ensembl peptide - ENSMUSP00000108571
Ensembl peptide - ENSMUSP00000115424
NCBI entrez gene - 110157     See in Manteia.
MGI - MGI:97847
RefSeq - XM_006505363
RefSeq - XM_006505365
RefSeq - XM_006505364
RefSeq - NM_001356334
RefSeq - NM_029780
RefSeq Peptide - NP_001343263
RefSeq Peptide - NP_084056
swissprot - Q99N57
swissprot - A0A0N4SWH5
swissprot - A0A0N4SV36
swissprot - F6TUC4
Ensembl - ENSMUSG00000000441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 raf1aENSDARG00000102328Danio rerio
 raf1aENSDARG00000096415Danio rerio
 raf1bENSDARG00000059406Danio rerio
 RAF1ENSGALG00000004998Gallus gallus
 RAF1ENSG00000132155Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000112757
Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*ENSMUSG0000000241356
Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*ENSMUSG0000001833425
Ksr2 / kinase suppressor of ras 2 / Q6VAB6*ENSMUSG0000006157824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0035994 response to muscle stretch IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045104 intermediate filament cytoskeleton organization IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0060324 face development IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071550 death-inducing signaling complex assembly IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031143 pseudopodium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008179 adenylate cyclase binding IEA
 molecular_functionGO:0010856 adenylate cyclase activator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm3Unc/Acetm3Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Faslpr/Faslpr,Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * 129T2/SvEms

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000441 wide skull 
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000447 flattened snout 
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Raf1tm2.1Ara/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cops6Gt(RRI087)Byg/Cops6+,Trp53tm1Glo/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Bmp7tm1Kry/Bmp7tm1Kry
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * 129T2/SvEms

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001711 abnormal placenta 
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * 129T2/SvEms

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp7tm1Kry/Bmp7tm1Kry
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Raf1tm1Ulb/Raf1tm1Ulb
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm2.1Ara/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Krastm1Bbd/Kras+,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargc1btm1.1Avp/Ppargc1btm1.1Avp
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2tm6Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Braftm1Wds/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Braftm1Sva/Braftm1Sva,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003394 increased cardiac output "greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Braftm1Wds/Braf+,Raf1tm2Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm2Bacc/Raf1tm2Bacc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Faslpr/Faslpr,Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0008526 decreased skull width "having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0008727 enlarged right atrium "increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
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Allelic Composition: Krastm4Tyj/Kras+,Raf1tm2Bacc/Raf1tm2Bacc,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0010031 abnormal cranium size "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0010283 decreased classified tumor incidence "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Bbd/Kras+,Raf1tm2Bacc/Raf1tm2Bacc
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0010583 abnormal conotruncus morphology "any structural anomaly of the distal portion of the bulbus cordis that will give rise to the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Braftm1Sva/Braftm1Sva,Raf1tm2Bacc/Raf1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Braftm1Sva/Braftm1.1Sva,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Braftm1Wds/Braftm1.1Wds,Raf1tm1Bacc/Raf1tm2Bacc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Braftm1Wds/Braftm1Wds,Raf1tm2Bacc/Raf1tm2Bacc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * 129T2/SvEms

Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Raf1tm1.1Bgn/Raf1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012244 increased hepatoblast apoptosis "increase in the number of hepatoblasts undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Acetm1Keb/Acetm5Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Raf1tm1Bacc/Raf1tm1Bacc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / reaction / complex
 ENSMUSG00000019970 Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / reaction / complex
 ENSMUSG00000025915 Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*  / complex
 ENSMUSG00000031431 Q9Z2S7 / Tsc22d3 / TSC22 domain family protein 3 / Q99576* / TSC22 domain family member 3*  / complex
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / reaction / complex
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / complex / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000017868 Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*  / complex
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / reaction / complex
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000032959 Pebp1 / P70296 / phosphatidylethanolamine binding protein 1 / P30086*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000055725 Paqr3 / Q6TCG8 / progestin and adipoQ receptor family member III / Q6TCH7* / progestin and adipoQ receptor family member 3*  / complex / reaction
 ENSMUSG00000047104 Pbp2 / PEBP1* / P30086* / phosphatidylethanolamine binding protein 1*  / complex / reaction






 

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