ENSMUSG00000025915


Mus musculus

Features
Gene ID: ENSMUSG00000025915
  
Biological name :Sgk3
  
Synonyms : Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Sgk3
  
Possible biological names infered from orthology : Q96BR1 / serum/glucocorticoid regulated kinase family member 3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A2
Gene start: 9798107
Gene end: 9900845
  
Corresponding Affymetrix probe sets: 10344750 (MoGene1.0st)   1420918_at (Mouse Genome 430 2.0 Array)   1420919_at (Mouse Genome 430 2.0 Array)   1450036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130078
Ensembl peptide - ENSMUSP00000140496
Ensembl peptide - ENSMUSP00000140318
Ensembl peptide - ENSMUSP00000139942
Ensembl peptide - ENSMUSP00000095437
Ensembl peptide - ENSMUSP00000126861
Ensembl peptide - ENSMUSP00000127462
NCBI entrez gene - 170755     See in Manteia.
MGI - MGI:2182368
RefSeq - NM_001037759
RefSeq - NM_133220
RefSeq - NM_177547
RefSeq Peptide - NP_573483
RefSeq Peptide - NP_808215
RefSeq Peptide - NP_001032848
swissprot - Q9ERE3
swissprot - A0A087WQS1
swissprot - A0A087WPW2
swissprot - A0A087WR70
Ensembl - ENSMUSG00000025915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk3ENSDARG00000062460Danio rerio
 SGK3ENSGALG00000043570Gallus gallus
 SGK3ENSG00000104205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997059
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786849
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110835
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764335
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503835
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969934
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172934
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096534
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194834
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405634
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881633
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288933
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677833
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905333


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001683  Phox homologous domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032411 positive regulation of transporter activity IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005246 calcium channel regulator activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IBA
 molecular_functionGO:0017081 chloride channel regulator activity IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3sf/Y
Genetic Background: either: 129Rl.Cg-Foxp3sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

 MP:0000384 distorted hair follicle pattern "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000389 disorganized outer root sheath cells "disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis" [J:56777]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000392 accelerated hair follicle regression "quicker than average length of time for onset of catagen phase of the cyclic transformation of the hair follicle" [J:65034]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

Allelic Composition: Sgk3fz-Mdf/Sgk3fz-Mdf
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Sgk3m1Btlr/Sgk3m1Btlr
Genetic Background: C57BL/6J-Sgk3m1Btlr

Allelic Composition: Sgk3fz-2J/Sgk3fz-2J
Genetic Background: AKR/J

Allelic Composition: Sgk3fz-4J/Sgk3fz-4J
Genetic Background: involves: C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sgk3fz-Mdf/Sgk3fz-Mdf
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0001278 kinked vibrissae "sharp bends in the vibrissae" [J:56641]
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Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0001279 wavy vibrissae "whiskers having undulations or a sinusoidal shape" [J:65044]
Show

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

Allelic Composition: Sgk3fz-Mdf/Sgk3fz-Mdf
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Sgk3fz-2J/Sgk3fz-2J
Genetic Background: AKR/J

Allelic Composition: Sgk3fz-4J/Sgk3fz-4J
Genetic Background: involves: C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3fz-2J/Sgk3fz-2J
Genetic Background: AKR/J

Allelic Composition: Sgk3fz-4J/Sgk3fz-4J
Genetic Background: involves: C57BL/6J

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3sf/Y
Genetic Background: either: 129Rl.Cg-Foxp3sf or (involves: 101/Rl * C3Hf/Rl * STOCK MR)

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-38H/Kit+
Genetic Background: Not Specified

Allelic Composition: Sgk3fz-4J/Sgk3fz-4J
Genetic Background: involves: C57BL/6J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003813 abnormal dermal papilla "abnormalities in this specialized group of mesenchymal cells necessary for initiation of follicle development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

 MP:0009351 thin hair shaft "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

Allelic Composition: Sgk3tm1Efu/Sgk3tm1Efu
Genetic Background: involves: 129P2/OlaHsd

 MP:0010681 abnormal hair follicle bulb morphology "any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells" [PMID:19211055]
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Allelic Composition: Sgk3fz/Sgk3fz
Genetic Background: CFW stock

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010690 thick hair follicle outer rooth sheath "increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

 MP:0010693 thin hair follicle inner rooth sheath "reduced thickness of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgk3ypc/Sgk3ypc
Genetic Background: YPC

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / complex
 ENSMUSG00000031431 Q9Z2S7 / Tsc22d3 / TSC22 domain family protein 3 / Q99576* / TSC22 domain family member 3*  / complex






 

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