| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Pou3f4sdl/Y
Genetic Background: C3HeB/FeJ-Pou3f4sdl
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| MP:0001152 | Leydig cell hyperplasia | "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N
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| MP:0001750 | increased circulating follicle stimulating hormone level | "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0001765 | abnormal ion homeostasis | "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N
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| MP:0001776 | abnormal circulating sodium level | "anomalous concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
Allelic Composition: Tsc22d3tm1.1Hum/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6N * FVB
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| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N
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| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0002310 | resistance to fatty liver development | "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0002425 | altered susceptibility to autoimmune disorder | "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
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| MP:0002665 | decreased circulating corticosterone level | "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0002685 | abnormal proliferation of spermatogonia | "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
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| MP:0002776 | Sertoli cell hyperplasia | "increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0002781 | increased circulating testosterone level | "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0003944 | abnormal T cell subpopulation ratio | "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator] |
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
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| MP:0004849 | abnormal testis size | "anomaly in the size of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
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| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
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| MP:0004956 | decreased thymus weight | "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
Allelic Composition: Tsc22d3tm1.1Hum/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6N * FVB
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| MP:0005418 | abnormal circulating hormone level | "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0005459 | decreased percent body fat | "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0005617 | increased susceptibility to type IV hypersensitivity reaction | "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
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| MP:0005627 | increased circulating potassium level | "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0005666 | abnormal adipose tissue physiology | "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
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| MP:0008261 | arrest of male meiosis | "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
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| MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified
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| MP:0008827 | abnormal thymus cell ratio | "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0009176 | increased pancreatic alpha cell number | "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0010134 | decreased DN3 thymocyte number | "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0010135 | increased DN4 thymocyte number | "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0011178 | increased erythroblast number | "greater number of the nucleated precursor of erythrocytes" [MGI:csmith] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
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| MP:0011750 | abnormal seminiferous tubule epithelium morphology | "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith] |
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Allelic Composition: Tsc22d3tm1.2Hum/Y
Genetic Background: involves: 129S1/SvImJ
Allelic Composition: Tsc22d3tm1.1Hum/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6N * FVB
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