ENSMUSG00000017868


Mus musculus

Features
Gene ID: ENSMUSG00000017868
  
Biological name :Sgk2
  
Synonyms : Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Sgk2
  
Possible biological names infered from orthology : Q9HBY8 / SGK2, serine/threonine kinase 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H2
Gene start: 162987330
Gene end: 163014127
  
Corresponding Affymetrix probe sets: 10478326 (MoGene1.0st)   1418739_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018012
Ensembl peptide - ENSMUSP00000112468
NCBI entrez gene - 27219     See in Manteia.
MGI - MGI:1351318
RefSeq - XM_011239580
RefSeq - NM_001291152
RefSeq - NM_001291154
RefSeq - NM_013731
RefSeq - XM_006499658
RefSeq - XM_006499660
RefSeq Peptide - NP_001278081
RefSeq Peptide - NP_001278083
RefSeq Peptide - NP_038759
swissprot - Q9QZS5
Ensembl - ENSMUSG00000017868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk2aENSDARG00000063370Danio rerio
 SGK2ENSGALG00000003537Gallus gallus
 SGK2ENSG00000101049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997069
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591566
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969944
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172943
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405643
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503841
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905340
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764340
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110840
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194839
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096539
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677838
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288938
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881638


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032411 positive regulation of transporter activity IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005246 calcium channel regulator activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IBA
 molecular_functionGO:0017081 chloride channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000031431 Q9Z2S7 / Tsc22d3 / TSC22 domain family protein 3 / Q99576* / TSC22 domain family member 3*  / complex
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / complex






 

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