ENSMUSG00000050965


Mus musculus

Features
Gene ID: ENSMUSG00000050965
  
Biological name :Prkca
  
Synonyms : Prkca / protein kinase C, alpha
  
Possible biological names infered from orthology : P17252
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 107933387
Gene end: 108343928
  
Corresponding Affymetrix probe sets: 10392388 (MoGene1.0st)   1427562_a_at (Mouse Genome 430 2.0 Array)   1437393_at (Mouse Genome 430 2.0 Array)   1450945_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062392
Ensembl peptide - ENSMUSP00000097875
NCBI entrez gene - 18750     See in Manteia.
MGI - MGI:97595
RefSeq - NM_011101
RefSeq Peptide - NP_035231
swissprot - Q3TQ39
swissprot - Q4VA93
Ensembl - ENSMUSG00000050965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcaENSDARG00000115657Danio rerio
 PRKCAENSDARG00000099841Danio rerio
 PRKCAENSGALG00000025950Gallus gallus
 PRKCAENSG00000154229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288981
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881672
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503845
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194841
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677841
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110841
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764332
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905332
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172927
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405627
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969926
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997025
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591525
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034663  Classical Protein Kinase C alpha, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002159 desmosome assembly IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035408 histone H3-T6 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0090330 regulation of platelet aggregation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Prkcatm1Jmk/Prkcatm1Jmk
Genetic Background: involves: 129

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032128 Robo3 / roundabout guidance receptor 3 / Q96MS0*  / complex / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / reaction
 ENSMUSG00000069662 Marcks / P26645 / Myristoylated alanine-rich C-kinase substrate / P29966* / myristoylated alanine rich protein kinase C substrate*  / reaction
 ENSMUSG00000021057 Akap5 / D3YVF0 / A-kinase anchor protein 5 / P24588* / A-kinase anchoring protein 5*  / reaction / complex
 ENSMUSG00000040028 Elavl1 / P70372 / ELAV-like protein 1 / Q15717* / ELAV like RNA binding protein 1*  / reaction
 ENSMUSG00000027882 Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000001964 Emd / O08579 / Emerin / P50402*  / reaction
 ENSMUSG00000061878 Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*  / reaction






 

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