ENSMUSG00000069662


Mus musculus

Features
Gene ID: ENSMUSG00000069662
  
Biological name :Marcks
  
Synonyms : Marcks / Myristoylated alanine-rich C-kinase substrate / P26645
  
Possible biological names infered from orthology : myristoylated alanine rich protein kinase C substrate / P29966
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B1
Gene start: 37133375
Gene end: 37138920
  
Corresponding Affymetrix probe sets: 10368675 (MoGene1.0st)   1415971_at (Mouse Genome 430 2.0 Array)   1415972_at (Mouse Genome 430 2.0 Array)   1415973_at (Mouse Genome 430 2.0 Array)   1430311_at (Mouse Genome 430 2.0 Array)   1437034_x_at (Mouse Genome 430 2.0 Array)   1456028_x_at (Mouse Genome 430 2.0 Array)   1456700_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090245
NCBI entrez gene - 17118     See in Manteia.
MGI - MGI:96907
RefSeq - NM_008538
RefSeq Peptide - NP_032564
swissprot - P26645
Ensembl - ENSMUSG00000069662
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 marcksaENSDARG00000004049Danio rerio
 marcksbENSDARG00000008803Danio rerio
 MARCKSENSGALG00000037726Gallus gallus
 MARCKSENSG00000277443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002101  Myristoylated alanine-rich C-kinase substrate MARCKS


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051017 actin filament bundle assembly IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051764 actin crosslink formation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032432 actin filament bundle IDA
 cellular_componentGO:0042585 germinal vesicle IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005516 calmodulin binding IPI
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0051015 actin filament binding IPI


Pathways (from Reactome)
Pathway description
Acetylcholine regulates insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0030178 abnormal scalp morphology "any structural anomaly of the soft tissue envelope of the cranial vault that extends from the external occipital protuberance and superior nuchal lines to the supraorbital margins; it consists of 5 layers: the skin (and head hair), connective tissue, epicranial aponeurosis, loose areolar tissue, and pericranium; the first 3 layers are bound together as a single unit that can move along the loose areolar tissue over the pericranium, which is adherent to the calvaria" []
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction






 

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