ENSMUSG00000037643


Mus musculus

Features
Gene ID: ENSMUSG00000037643
  
Biological name :Prkci
  
Synonyms : Prkci / protein kinase C, iota / Q62074
  
Possible biological names infered from orthology : P41743
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 30995747
Gene end: 31052959
  
Corresponding Affymetrix probe sets: 10491279 (MoGene1.0st)   1417410_s_at (Mouse Genome 430 2.0 Array)   1448695_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103884
Ensembl peptide - ENSMUSP00000119192
Ensembl peptide - ENSMUSP00000123671
NCBI entrez gene - 18759     See in Manteia.
MGI - MGI:99260
RefSeq - XM_006535411
RefSeq - NM_008857
RefSeq Peptide - NP_032883
swissprot - D3YXY0
swissprot - Q62074
swissprot - F6QWV4
Ensembl - ENSMUSG00000037643
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkciENSDARG00000021225Danio rerio
 PRKCIENSGALG00000009364Gallus gallus
 PRKCIENSG00000163558Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905372
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110838
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503838
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096537
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288936
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881634
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194833
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677833
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591529
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969929
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172929
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405628
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997027
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034661  Atypical protein kinase C iota type, catalytic domain
 IPR034877  Protein kinase C, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035089 establishment of apical/basal cell polarity IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0048194 Golgi vesicle budding IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001318 pupil opacity "milky or cloudy appearance of the central circular aperture of the iris through which light rays normally enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001320 small pupils "smaller than normal size of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
Genetic Background: involves: 129P2/OlaHsd * NMRI

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atf2tm2Nicj/Atf2tm2Nicj,Atf7tm1Nicj/Atf7tm1Nicj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0005199 abnormal iris pigment epithelium "anomaly in the epithelial layer of the iris composed of cells containing pigment granules " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkcitm1Kido/Prkcitm1.1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0008060 abnormal podocyte slit diaphragm morphology "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008062 abnormal podocyte slit junction morphology "any structural anomaly in the gaps between the interdigitated foot processes of the podocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008583 absent photoreceptor inner segment "absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prkcitm2.1(Prkcz)Ltg/Prkcitm2.1(Prkcz)Ltg
Genetic Background: involves: 129P2/OlaHsd * NMRI

 MP:0011190 thick embryonic epiblast "increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011753 decreased podocyte number "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011869 detached podocyte "detachment or loss of adhesion of podocyte foot processes from the glomerular basement membrane (GBM); as a consequence, denuded GBM areas at peripheral capillary loops can become foci for adhesions to parietal epithelial cells (glomerular synechiae) and crescent formation, and podocytes and podocyte-specific proteins may be found in the urine" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011870 abnormal podocyte polarity "any anomaly in the establishment or maintenance of podocyte cell polarity; podocytes exhibit polarity along at least two axes: (i) an apical-basal axis perpendicular to the glomerular basement membrane in which the apical and basolateral membrane domains of the podocyte are separated by a boundary created by the intercellular junctions of the foot process and (ii) a second plane parallel to the basement membrane that determines the unique orientation of interdigitating foot processes" [MGI:anna]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0012104 small amniotic cavity "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0030020 decreased cardiac cell glucose uptake "reduced ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Prkcitm1Rfar/Prkcitm1Rfar
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000015837 Q64337 / Sqstm1 / Sequestosome-1 / Q13501*  / reaction / complex
 ENSMUSG00000025812 Pard3 / Q99NH2 / par-3 family cell polarity regulator / Q8TEW0*  / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000056214 Pard6g / Q9JK84 / Partitioning defective 6 homolog gamma / Q9BYG4* / par-6 family cell polarity regulator gamma*  / complex
 ENSMUSG00000044641 Pard6b / Q9JK83 / Partitioning defective 6 homolog beta / Q9BYG5* / par-6 family cell polarity regulator beta*  / complex
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / complex
 ENSMUSG00000038235 F11r / O88792 / Junctional adhesion molecule A / Q9Y624* / F11 receptor*  / complex / reaction
 ENSMUSG00000003051 Elf3 / Q3UPW2 / ETS-related transcription factor Elf-3 / P78545* / E74 like ETS transcription factor 3*  / reaction






 

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