ENSMUSG00000038235


Mus musculus

Features
Gene ID: ENSMUSG00000038235
  
Biological name :F11r
  
Synonyms : F11r / Junctional adhesion molecule A / O88792
  
Possible biological names infered from orthology : F11 receptor / Q9Y624
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171437535
Gene end: 171464603
  
Corresponding Affymetrix probe sets: 10351623 (MoGene1.0st)   1424595_at (Mouse Genome 430 2.0 Array)   1436374_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041907
NCBI entrez gene - 16456     See in Manteia.
MGI - MGI:1321398
RefSeq - NM_172647
RefSeq Peptide - NP_766235
swissprot - O88792
Ensembl - ENSMUSG00000038235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f11r.1ENSDARG00000017320Danio rerio
 f11r.2ENSDARG00000068114Danio rerio
 F11RENSG00000158769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jam2 / Q9JI59 / Junctional adhesion molecule B / P57087* / junctional adhesion molecule 2*ENSMUSG0000005306233
Jam3 / Q9D8B7 / Junctional adhesion molecule C / Q9BX67* / junctional adhesion molecule 3*ENSMUSG0000003199032


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IMP
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030855 epithelial cell differentiation IDA
 biological_processGO:0031032 actomyosin structure organization IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0050892 intestinal absorption IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 biological_processGO:0090559 regulation of membrane permeability IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036057 slit diaphragm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025812 Pard3 / Q99NH2 / par-3 family cell polarity regulator / Q8TEW0*  / complex / reaction
 ENSMUSG00000038235 F11r / O88792 / Junctional adhesion molecule A / Q9Y624* / F11 receptor*  / complex / reaction
 ENSMUSG00000056214 Pard6g / Q9JK84 / Partitioning defective 6 homolog gamma / Q9BYG4* / par-6 family cell polarity regulator gamma*  / reaction / complex
 ENSMUSG00000044641 Pard6b / Q9JK83 / Partitioning defective 6 homolog beta / Q9BYG5* / par-6 family cell polarity regulator beta*  / complex / reaction
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / reaction / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / complex / reaction
 ENSMUSG00000030830 Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr