ENSMUSG00000025812


Mus musculus

Features
Gene ID: ENSMUSG00000025812
  
Biological name :Pard3
  
Synonyms : par-3 family cell polarity regulator / Pard3 / Q99NH2
  
Possible biological names infered from orthology : Q8TEW0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 127063893
Gene end: 127612286
  
Corresponding Affymetrix probe sets: 10576610 (MoGene1.0st)   1420391_at (Mouse Genome 430 2.0 Array)   1434775_at (Mouse Genome 430 2.0 Array)   1436764_at (Mouse Genome 430 2.0 Array)   1436765_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124359
Ensembl peptide - ENSMUSP00000125612
Ensembl peptide - ENSMUSP00000125610
Ensembl peptide - ENSMUSP00000125453
Ensembl peptide - ENSMUSP00000125450
Ensembl peptide - ENSMUSP00000125212
Ensembl peptide - ENSMUSP00000125064
Ensembl peptide - ENSMUSP00000124934
Ensembl peptide - ENSMUSP00000124789
Ensembl peptide - ENSMUSP00000124733
Ensembl peptide - ENSMUSP00000124718
Ensembl peptide - ENSMUSP00000124533
Ensembl peptide - ENSMUSP00000124441
Ensembl peptide - ENSMUSP00000026921
Ensembl peptide - ENSMUSP00000078710
Ensembl peptide - ENSMUSP00000104383
Ensembl peptide - ENSMUSP00000123944
Ensembl peptide - ENSMUSP00000123951
Ensembl peptide - ENSMUSP00000124141
Ensembl peptide - ENSMUSP00000124162
Ensembl peptide - ENSMUSP00000124282
Ensembl peptide - ENSMUSP00000124319
Ensembl peptide - ENSMUSP00000124339
NCBI entrez gene - 93742     See in Manteia.
MGI - MGI:2135608
RefSeq - XM_006531533
RefSeq - XM_006531532
RefSeq - XM_006531531
RefSeq - XM_006531530
RefSeq - XM_006531529
RefSeq - XM_006531528
RefSeq - XM_006531527
RefSeq - XM_006531526
RefSeq - XM_006531524
RefSeq - XM_006531523
RefSeq - XM_006531521
RefSeq - XM_006531520
RefSeq - NM_033620
RefSeq - NM_001309392
RefSeq - NM_001309391
RefSeq - NM_001122850
RefSeq - NM_001013581
RefSeq - NM_001013580
RefSeq Peptide - NP_001116322
RefSeq Peptide - NP_001013598
RefSeq Peptide - NP_001013599
RefSeq Peptide - NP_001296320
RefSeq Peptide - NP_001296321
RefSeq Peptide - NP_296369
swissprot - F6T4Y3
swissprot - E0CXR8
swissprot - E0CY24
swissprot - E9PYJ2
swissprot - E0CYB6
swissprot - E0CZ83
swissprot - E0CZE2
swissprot - Q4JJC0
swissprot - Q99NH2
swissprot - F6S7Z1
swissprot - A0A0R4J1Y4
swissprot - A5D6P2
swissprot - B7ZNY3
swissprot - E0CX45
swissprot - E0CXD3
swissprot - E0CXL4
swissprot - G3XA13
swissprot - F6URI7
swissprot - F6UGU7
swissprot - F6TSJ9
swissprot - F6TB42
Ensembl - ENSMUSG00000025812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PARD3 (1 of many)ENSDARG00000110804Danio rerio
 pard3abENSDARG00000010583Danio rerio
 PARD3ENSGALG00000007125Gallus gallus
 PARD3ENSG00000148498Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pard3b / Q9CSB4 / par-3 family cell polarity regulator beta / Q8TEW8*ENSMUSG0000005206236
Pdzd2 / PDZ domain containing 2 / O15018*ENSMUSG0000002219716
Mpdz / Q8VBX6 / multiple PDZ domain protein / O75970* / multiple PDZ domain crumbs cell polarity complex component*ENSMUSG0000002840215
Patj / Q63ZW7 / Mus musculus PATJ, crumbs cell polarity complex component (Patj), transcript variant 5, mRNA. / Q8NI35* / PATJ, crumbs cell polarity complex component*ENSMUSG0000006185915
Il16 / O54824 / Pro-interleukin-16 Interleukin-16 / Q14005* / interleukin 16*ENSMUSG0000000174112
Lnx1 / O70263 / ligand of numb-protein X 1 / Q8TBB1*ENSMUSG000000292289
Lnx2 / Q91XL2 / Ligand of Numb protein X 2 / Q8N448*ENSMUSG000000165208


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR021922  Par3/HAL, N-terminal
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0002092 positive regulation of receptor internalization IMP
 biological_processGO:0003383 apical constriction IGI
 biological_processGO:0006612 protein targeting to membrane ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032970 regulation of actin filament-based process IGI
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0060341 regulation of cellular localization IEA
 biological_processGO:0070830 bicellular tight junction assembly ISS
 biological_processGO:0090162 establishment of epithelial cell polarity ISS
 biological_processGO:0098609 cell-cell adhesion IC
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0033269 internode region of axon IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043219 lateral loop IDA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0043296 apical junction complex IDA
 cellular_componentGO:0044295 axonal growth cone IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding ISS
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004055 atrial hypoplasia "reduction in cell number of one or both of the two upper chambers of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36567]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038235 F11r / O88792 / Junctional adhesion molecule A / Q9Y624* / F11 receptor*  / reaction / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / complex
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / complex
 ENSMUSG00000029053 Prkcz / Q02956 / protein kinase C, zeta / Q05513*  / complex
 ENSMUSG00000056214 Pard6g / Q9JK84 / Partitioning defective 6 homolog gamma / Q9BYG4* / par-6 family cell polarity regulator gamma*  / complex
 ENSMUSG00000044641 Pard6b / Q9JK83 / Partitioning defective 6 homolog beta / Q9BYG5* / par-6 family cell polarity regulator beta*  / complex






 

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