ENSMUSG00000005699


Mus musculus

Features
Gene ID: ENSMUSG00000005699
  
Biological name :Pard6a
  
Synonyms : Pard6a / Partitioning defective 6 homolog alpha / Q9Z101
  
Possible biological names infered from orthology : par-6 family cell polarity regulator alpha / Q9NPB6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105701148
Gene end: 105703496
  
Corresponding Affymetrix probe sets: 10574866 (MoGene1.0st)   1449100_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090886
Ensembl peptide - ENSMUSP00000148508
Ensembl peptide - ENSMUSP00000148603
Ensembl peptide - ENSMUSP00000148821
Ensembl peptide - ENSMUSP00000096043
NCBI entrez gene - 56513     See in Manteia.
MGI - MGI:1927223
RefSeq - NM_001047436
RefSeq - NM_001047435
RefSeq - NM_001286344
RefSeq - NM_001286345
RefSeq - NM_019695
RefSeq Peptide - NP_062669
RefSeq Peptide - NP_001040900
RefSeq Peptide - NP_001040901
RefSeq Peptide - NP_001273273
RefSeq Peptide - NP_001273274
swissprot - Q9Z101
swissprot - D3Z2R1
swissprot - Q3TY70
swissprot - A0A1D5RLU4
Ensembl - ENSMUSG00000005699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pard6aENSDARG00000069378Danio rerio
 PARD6AENSGALG00000001214Gallus gallus
 PARD6AENSG00000102981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pard6b / Q9JK83 / Partitioning defective 6 homolog beta / Q9BYG5* / par-6 family cell polarity regulator beta*ENSMUSG0000004464151
Pard6g / Q9JK84 / Partitioning defective 6 homolog gamma / Q9BYG4* / par-6 family cell polarity regulator gamma*ENSMUSG0000005621450


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR001478  PDZ domain
 IPR034868  Partitioning defective protein 6, PB1 domain
 IPR034872  Partitioning defective 6 homologue alpha
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IEA
 biological_processGO:0030010 establishment of cell polarity TAS
 biological_processGO:0045217 cell-cell junction maintenance IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1904781 positive regulation of protein localization to centrosome IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction TAS
 cellular_componentGO:0034451 centriolar satellite IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IDA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

 MP:0013436 increased CD8-positive, naive alpha-beta T cell number "increase in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
Show

Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex
 ENSMUSG00000025812 Pard3 / Q99NH2 / par-3 family cell polarity regulator / Q8TEW0*  / complex
 ENSMUSG00000029053 Prkcz / Q02956 / protein kinase C, zeta / Q05513*  / complex
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000038235 F11r / O88792 / Junctional adhesion molecule A / Q9Y624* / F11 receptor*  / reaction / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / complex






 

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