ENSG00000102981


Homo sapiens

Features
Gene ID: ENSG00000102981
  
Biological name :PARD6A
  
Synonyms : par-6 family cell polarity regulator alpha / PARD6A / Q9NPB6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 67660946
Gene end: 67662778
  
Corresponding Affymetrix probe sets: 205245_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000219255
Ensembl peptide - ENSP00000392388
Ensembl peptide - ENSP00000473257
NCBI entrez gene - 50855     See in Manteia.
OMIM - 607484
RefSeq - XM_017023261
RefSeq - NM_001037281
RefSeq - NM_016948
RefSeq - XM_005255977
RefSeq - XM_011523095
RefSeq - XM_011523096
RefSeq Peptide - NP_001032358
RefSeq Peptide - NP_058644
swissprot - Q9NPB6
swissprot - R4GMM2
Ensembl - ENSG00000102981
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pard6aENSDARG00000069378Danio rerio
 PARD6AENSGALG00000001214Gallus gallus
 Pard6aENSMUSG00000005699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARD6G / Q9BYG4 / par-6 family cell polarity regulator gammaENSG0000017818451
PARD6B / Q9BYG5 / par-6 family cell polarity regulator betaENSG0000012417150


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR001478  PDZ domain
 IPR034868  Partitioning defective protein 6, PB1 domain
 IPR034872  Partitioning defective 6 homologue alpha
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0007163 establishment or maintenance of cell polarity IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0016032 viral process TAS
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0070830 bicellular tight junction assembly TAS
 biological_processGO:1904781 positive regulation of protein localization to centrosome IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034451 centriolar satellite IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198742 Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1  / reaction / complex
 ENSG00000108854 Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000148498 PARD3 / Q8TEW0 / par-3 family cell polarity regulator  / complex
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / complex / reaction
 ENSG00000067606 PRKCZ / Q05513 / protein kinase C zeta  / complex






 

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