ENSG00000198742


Homo sapiens

Features
Gene ID: ENSG00000198742
  
Biological name :SMURF1
  
Synonyms : Q9HCE7 / SMAD specific E3 ubiquitin protein ligase 1 / SMURF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 99027438
Gene end: 99144100
  
Corresponding Affymetrix probe sets: 212666_at (Human Genome U133 Plus 2.0 Array)   212668_at (Human Genome U133 Plus 2.0 Array)   215458_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354621
Ensembl peptide - ENSP00000355326
NCBI entrez gene - 57154     See in Manteia.
OMIM - 605568
RefSeq - XM_017012457
RefSeq - NM_001199847
RefSeq - NM_020429
RefSeq - NM_181349
RefSeq Peptide - NP_065162
RefSeq Peptide - NP_851994
RefSeq Peptide - NP_001186776
swissprot - Q9HCE7
Ensembl - ENSG00000198742
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smurf1ENSDARG00000016086Danio rerio
 SMURF1ENSGALG00000004655Gallus gallus
 Q9CUN6ENSMUSG00000038780Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2ENSG0000010885475
ITCH / Q96J02 / itchy E3 ubiquitin protein ligaseENSG0000007874739
NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG0000004975938
WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1ENSG0000012312438
WWP2 / O00308 / WW domain containing E3 ubiquitin protein ligase 2ENSG0000019837336
NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseENSG0000006986936
HECW1 / Q76N89 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1ENSG0000000274635
HECW2 / Q9P2P5 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2ENSG0000013841134
HACE1 / Q8IYU2 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1ENSG0000008538227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007398 ectoderm development TAS
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway TAS
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IDA
 biological_processGO:0032801 receptor catabolic process IDA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0061736 engulfment of target by autophagosome IMP
 biological_processGO:0061753 substrate localization to autophagosome IMP
 biological_processGO:0071211 protein targeting to vacuole involved in autophagy IMP
 biological_processGO:0072659 protein localization to plasma membrane TAS
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IGI
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048185 activin binding NAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0070411 I-SMAD binding IPI
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog on state
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000102981 PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha  / complex / reaction
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / complex / reaction
 ENSG00000138696 BMPR1B / O00238 / bone morphogenetic protein receptor type 1B  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction
 ENSG00000137834 SMAD6 / O43541 / SMAD family member 6  / complex
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000185920 PTCH1 / Q13635 / patched 1  / reaction / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / complex / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / complex / reaction
 ENSG00000082898 XPO1 / O14980 / exportin 1  / complex / reaction
 ENSG00000204217 BMPR2 / Q13873 / bone morphogenetic protein receptor type 2  / reaction / complex
 ENSG00000107779 BMPR1A / P36894 / bone morphogenetic protein receptor type 1A  / complex / reaction
 ENSG00000125845 BMP2 / P12643 / bone morphogenetic protein 2  / reaction / complex






 

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