ENSG00000123124


Homo sapiens

Features
Gene ID: ENSG00000123124
  
Biological name :WWP1
  
Synonyms : Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1 / WWP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.3
Gene start: 86342738
Gene end: 86478420
  
Corresponding Affymetrix probe sets: 212637_s_at (Human Genome U133 Plus 2.0 Array)   212638_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265428
Ensembl peptide - ENSP00000427793
Ensembl peptide - ENSP00000429076
Ensembl peptide - ENSP00000430228
NCBI entrez gene - 11059     See in Manteia.
OMIM - 602307
RefSeq - XM_017012997
RefSeq - XM_017012993
RefSeq - XM_017012994
RefSeq - XM_017012995
RefSeq - XM_017012996
RefSeq - NM_007013
RefSeq - XM_005250760
RefSeq - XM_005250761
RefSeq - XM_011516802
RefSeq Peptide - NP_008944
swissprot - H0YBS9
swissprot - H0YBA4
swissprot - Q9H0M0
Ensembl - ENSG00000123124
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwp1ENSDARG00000097537Danio rerio
 WWP1ENSGALG00000041795Gallus gallus
 Wwp1ENSMUSG00000041058Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WWP2 / O00308 / WW domain containing E3 ubiquitin protein ligase 2ENSG0000019837360
ITCH / Q96J02 / itchy E3 ubiquitin protein ligaseENSG0000007874759
NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseENSG0000004975936
NEDD4 / P46934 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseENSG0000006986934
HECW1 / Q76N89 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1ENSG0000000274633
HECW2 / Q9P2P5 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2ENSG0000013841132
Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2ENSG0000010885432
Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1ENSG0000019874231
HACE1 / Q8IYU2 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1ENSG0000008538223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007417 central nervous system development NAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0046718 viral entry into host cell TAS
 cellular_componentGO:0000151 ubiquitin ligase complex NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB4 signaling
Stimuli-sensing channels
Regulation of RUNX2 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000104205 SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3  / complex
 ENSG00000101049 SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2  / complex
 ENSG00000118515 SGK1 / O00141 / serum/glucocorticoid regulated kinase 1  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000157514 Q99576 / TSC22D3 / TSC22 domain family member 3  / complex
 ENSG00000127124 HIVEP3 / Q5T1R4 / human immunodeficiency virus type I enhancer binding protein 3  / reaction / complex






 

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