ENSG00000101049


Homo sapiens

Features
Gene ID: ENSG00000101049
  
Biological name :SGK2
  
Synonyms : Q9HBY8 / SGK2 / SGK2, serine/threonine kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 43558968
Gene end: 43588237
  
Corresponding Affymetrix probe sets: 220357_s_at (Human Genome U133 Plus 2.0 Array)   230573_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412214
Ensembl peptide - ENSP00000481432
Ensembl peptide - ENSP00000436841
Ensembl peptide - ENSP00000340608
Ensembl peptide - ENSP00000362168
Ensembl peptide - ENSP00000362184
Ensembl peptide - ENSP00000362192
Ensembl peptide - ENSP00000392795
Ensembl peptide - ENSP00000396222
NCBI entrez gene - 10110     See in Manteia.
OMIM - 607589
RefSeq - NM_001199264
RefSeq - NM_016276
RefSeq - NM_170693
RefSeq Peptide - NP_001186193
RefSeq Peptide - NP_733794
RefSeq Peptide - NP_057360
swissprot - X6R8H3
swissprot - F2Z3C8
swissprot - Q5H8Y5
swissprot - Q9HBY8
swissprot - A0A0G2JNI2
Ensembl - ENSG00000101049
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk2aENSDARG00000063370Danio rerio
 SGK2ENSGALG00000003537Gallus gallus
 Sgk2ENSMUSG00000017868Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851562
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420560
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522139
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220839
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702039
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113237
PRKCH / P24723 / protein kinase C etaENSG0000002707536
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760636
PRKCD / Q05655 / protein kinase C deltaENSG0000016393236
PRKCI / P41743 / protein kinase C iotaENSG0000016355835
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567534
PRKCG / P05129 / protein kinase C gammaENSG0000012658333
PRKCA / P17252 / protein kinase C alphaENSG0000015422933
PRKCB / P05771 / protein kinase C betaENSG0000016650133


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth TAS
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0006979 response to oxidative stress TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032411 positive regulation of transporter activity TAS
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005246 calcium channel regulator activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity TAS
 molecular_functionGO:0017081 chloride channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex
 ENSG00000049759 NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  / complex
 ENSG00000123124 WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1  / complex
 ENSG00000157514 Q99576 / TSC22D3 / TSC22 domain family member 3  / complex






 

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