ENSG00000027075


Homo sapiens

Features
Gene ID: ENSG00000027075
  
Biological name :PRKCH
  
Synonyms : P24723 / PRKCH / protein kinase C eta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.1
Gene start: 61187559
Gene end: 61550976
  
Corresponding Affymetrix probe sets: 206099_at (Human Genome U133 Plus 2.0 Array)   218764_at (Human Genome U133 Plus 2.0 Array)   230124_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452588
Ensembl peptide - ENSP00000452528
Ensembl peptide - ENSP00000491586
Ensembl peptide - ENSP00000329127
Ensembl peptide - ENSP00000450959
Ensembl peptide - ENSP00000450981
Ensembl peptide - ENSP00000451205
Ensembl peptide - ENSP00000451789
Ensembl peptide - ENSP00000451793
Ensembl peptide - ENSP00000451871
Ensembl peptide - ENSP00000451930
Ensembl peptide - ENSP00000451933
Ensembl peptide - ENSP00000452055
Ensembl peptide - ENSP00000452129
Ensembl peptide - ENSP00000452330
NCBI entrez gene - 5583     See in Manteia.
OMIM - 605437
RefSeq - XM_017021459
RefSeq - NM_006255
RefSeq - XM_011536954
RefSeq - XM_011536955
RefSeq - XM_011536956
RefSeq - XM_011536957
RefSeq - XM_017021458
RefSeq Peptide - NP_006246
swissprot - G3V4X4
swissprot - G3V520
swissprot - G3V5F8
swissprot - G3V5U5
swissprot - G3V5Y6
swissprot - A0A1W2PPU0
swissprot - P24723
swissprot - G3V304
swissprot - G3V3E7
swissprot - G3V4G6
swissprot - G3V4H0
swissprot - G3V4L3
swissprot - G3V4Q9
swissprot - G3V4Q6
Ensembl - ENSG00000027075
  
Related genetic diseases (OMIM): 601367 - {Cerebral infarction, susceptibility to}, 601367
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkchaENSDARG00000018382Danio rerio
 prkchbENSDARG00000043243Danio rerio
 PRKCHENSGALG00000011889Gallus gallus
 PrkchENSMUSG00000021108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113265
PRKCB / P05771 / protein kinase C betaENSG0000016650141
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567541
PRKCD / Q05655 / protein kinase C deltaENSG0000016393241
PRKCA / P17252 / protein kinase C alphaENSG0000015422940
PRKCG / P05129 / protein kinase C gammaENSG0000012658340
PRKCI / P41743 / protein kinase C iotaENSG0000016355833
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760632
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220827
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851526
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702026
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522126
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420525
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027431  Protein kinase C, eta
 IPR034665  Novel protein kinase C eta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation ISS
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060252 positive regulation of glial cell proliferation IMP
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane TAS
 biological_processGO:2000810 regulation of bicellular tight junction assembly IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity TAS
 molecular_functionGO:0004699 calcium-independent protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
G alpha (z) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr