ENSG00000163558


Homo sapiens

Features
Gene ID: ENSG00000163558
  
Biological name :PRKCI
  
Synonyms : P41743 / PRKCI / protein kinase C iota
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.2
Gene start: 170222365
Gene end: 170305981
  
Corresponding Affymetrix probe sets: 209677_at (Human Genome U133 Plus 2.0 Array)   209678_s_at (Human Genome U133 Plus 2.0 Array)   213518_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295797
NCBI entrez gene - 5584     See in Manteia.
OMIM - 600539
RefSeq - NM_002740
RefSeq - XM_017006860
RefSeq Peptide - NP_002731
swissprot - P41743
Ensembl - ENSG00000163558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkciENSDARG00000021225Danio rerio
 PRKCIENSGALG00000009364Gallus gallus
 PrkciENSMUSG00000037643Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760671
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113239
PRKCH / P24723 / protein kinase C etaENSG0000002707538
PRKCA / P17252 / protein kinase C alphaENSG0000015422937
PRKCB / P05771 / protein kinase C betaENSG0000016650136
PRKCG / P05129 / protein kinase C gammaENSG0000012658334
PRKCD / Q05655 / protein kinase C deltaENSG0000016393233
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567533
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420529
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702028
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522128
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220828
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851527
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034661  Atypical protein kinase C iota type, catalytic domain
 IPR034877  Protein kinase C, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006612 protein targeting to membrane NAS
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IMP
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035089 establishment of apical/basal cell polarity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042462 eye photoreceptor cell development IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity TAS
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway TAS
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046903 secretion NAS
 biological_processGO:0048194 Golgi vesicle budding IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0060252 positive regulation of glial cell proliferation IMP
 biological_processGO:0061024 membrane organization NAS
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0070830 bicellular tight junction assembly TAS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004697 protein kinase C activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102981 PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha  / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000148498 PARD3 / Q8TEW0 / par-3 family cell polarity regulator  / complex
 ENSG00000124171 PARD6B / Q9BYG5 / par-6 family cell polarity regulator beta  / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000163435 ELF3 / P78545 / E74 like ETS transcription factor 3  / reaction
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000178184 PARD6G / Q9BYG4 / par-6 family cell polarity regulator gamma  / complex
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / complex / reaction






 

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