ENSG00000148498


Homo sapiens

Features
Gene ID: ENSG00000148498
  
Biological name :PARD3
  
Synonyms : par-3 family cell polarity regulator / PARD3 / Q8TEW0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.21
Gene start: 34109560
Gene end: 34815325
  
Corresponding Affymetrix probe sets: 210094_s_at (Human Genome U133 Plus 2.0 Array)   221280_s_at (Human Genome U133 Plus 2.0 Array)   221526_x_at (Human Genome U133 Plus 2.0 Array)   221527_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443147
Ensembl peptide - ENSP00000440857
Ensembl peptide - ENSP00000444429
Ensembl peptide - ENSP00000311986
Ensembl peptide - ENSP00000340591
Ensembl peptide - ENSP00000341844
Ensembl peptide - ENSP00000363900
Ensembl peptide - ENSP00000363905
Ensembl peptide - ENSP00000363908
Ensembl peptide - ENSP00000363920
Ensembl peptide - ENSP00000363921
Ensembl peptide - ENSP00000363922
Ensembl peptide - ENSP00000363926
NCBI entrez gene - 56288     See in Manteia.
OMIM - 606745
RefSeq - XM_017016430
RefSeq - XM_005252534
RefSeq - XM_005252535
RefSeq - XM_005252536
RefSeq - XM_011519569
RefSeq - XM_011519570
RefSeq - XM_011519571
RefSeq - XM_011519572
RefSeq - XM_011519573
RefSeq - XM_011519575
RefSeq - XM_011519576
RefSeq - XM_011519577
RefSeq - XM_011519578
RefSeq - XM_011519579
RefSeq - XM_011519581
RefSeq - XM_011519583
RefSeq - XM_011519584
RefSeq - NM_001184785
RefSeq - NM_001184786
RefSeq - NM_001184787
RefSeq - NM_001184788
RefSeq - NM_001184789
RefSeq - NM_001184790
RefSeq - NM_001184791
RefSeq - NM_001184792
RefSeq - NM_001184793
RefSeq - NM_001184794
RefSeq - NM_019619
RefSeq - XM_005252528
RefSeq - XM_005252530
RefSeq - XM_005252531
RefSeq - XM_005252532
RefSeq Peptide - NP_001171721
RefSeq Peptide - NP_001171714
RefSeq Peptide - NP_001171715
RefSeq Peptide - NP_001171716
RefSeq Peptide - NP_001171717
RefSeq Peptide - NP_001171722
RefSeq Peptide - NP_001171723
RefSeq Peptide - NP_062565
RefSeq Peptide - NP_001171718
RefSeq Peptide - NP_001171719
RefSeq Peptide - NP_001171720
swissprot - Q5VWU8
swissprot - F5GZI3
swissprot - Q5VWV2
swissprot - Q8TEW0
swissprot - B1AP52
Ensembl - ENSG00000148498
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PARD3 (1 of many)ENSDARG00000110804Danio rerio
 pard3abENSDARG00000010583Danio rerio
 PARD3ENSGALG00000007125Gallus gallus
 Pard3ENSMUSG00000025812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARD3B / Q8TEW8 / par-3 family cell polarity regulator betaENSG0000011611737
PDZD2 / O15018 / PDZ domain containing 2ENSG0000013340116
PATJ / Q8NI35 / PATJ, crumbs cell polarity complex componentENSG0000013284915
MPDZ / O75970 / multiple PDZ domain crumbs cell polarity complex componentENSG0000010718615
IL16 / Q14005 / interleukin 16ENSG0000017234912
LNX1 / Q8TBB1 / ligand of numb-protein X 1ENSG000000722019
LNX2 / Q8N448 / ligand of numb-protein X 2ENSG000001395178


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR021922  Par3/HAL, N-terminal
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006612 protein targeting to membrane ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007409 axonogenesis TAS
 biological_processGO:0008356 asymmetric cell division TAS
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0022011 myelination in peripheral nervous system ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031643 positive regulation of myelination ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060341 regulation of cellular localization IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0070830 bicellular tight junction assembly TAS
 biological_processGO:0090162 establishment of epithelial cell polarity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0033269 internode region of axon ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding ISS
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102981 PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha  / complex
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / complex / reaction
 ENSG00000178184 PARD6G / Q9BYG4 / par-6 family cell polarity regulator gamma  / complex
 ENSG00000124171 PARD6B / Q9BYG5 / par-6 family cell polarity regulator beta  / complex
 ENSG00000067606 PRKCZ / Q05513 / protein kinase C zeta  / complex






 

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