ENSDARG00000010583


Danio rerio

Features
Gene ID: ENSDARG00000010583
  
Biological name :pard3ab
  
Synonyms : par-3 family cell polarity regulator alpha, b / pard3ab
  
Possible biological names infered from orthology : par-3 family cell polarity regulator / PARD3 / Q8TEW0 / Q99NH2
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 43204919
Gene end: 43389248
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000016375
Ensembl peptide - ENSDARP00000141632
Ensembl peptide - ENSDARP00000108968
Ensembl peptide - ENSDARP00000056401
NCBI entrez gene - 403050     See in Manteia.
RefSeq - NM_205735
RefSeq Peptide - NP_991298
swissprot - A2BEM5
swissprot - A2BEM7
swissprot - A0A0R4IZU1
swissprot - A2BEM6
ZFIN ID - ZDB-GENE-030925-47
Ensembl - ENSDARG00000010583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PARD3ENSGALG00000007125Gallus gallus
 PARD3ENSG00000148498Homo sapiens
 Pard3ENSMUSG00000025812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARD3 (1 of many) / par-3 family cell polarity regulator / PARD3* / Q8TEW0*ENSDARG0000011080426
pard3ba / si:ch1073-345a8.1 / PARD3B* / Q8TEW8* / par-3 family cell polarity regulator beta*ENSDARG0000009267124
pard3bb / par-3 family cell polarity regulator beta b / PARD3B* / Q9CSB4* / Q8TEW8* / par-3 family cell polarity regulator beta*ENSDARG0000003455520
pdzd2 / PDZ domain containing 2 / O15018*ENSDARG0000005980115
patj / PATJ, crumbs cell polarity complex component / Q63ZW7* / Q8NI35* / Mus musculus PATJ, crumbs cell polarity complex component (Patj), transcript variant 5, mRNA.*ENSDARG0000002496413
si:dkey-92j12.5 / MPDZ* / Q8VBX6* / O75970* / multiple PDZ domain protein* / multiple PDZ domain crumbs cell polarity complex component*ENSDARG0000009467712
il16 / interleukin 16 / O54824* / Q14005* / Pro-interleukin-16 Interleukin-16*ENSDARG0000010290810
lnx1 / ligand of numb-protein X 1 / O70263* / Q8TBB1*ENSDARG000000433239
lnx2b / ligand of numb-protein X 2bENSDARG000000714787
lnx2a / ligand of numb-protein X 2a / LNX2* / Q8N448* / Q91XL2* / ligand of numb-protein X 2*ENSDARG000000291777
si:dkey-92i15.4ENSDARG000000783873


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR021922  Par3/HAL, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0048048 embryonic eye morphogenesis IMP
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:0051660 establishment of centrosome localization IMP
 biological_processGO:0060242 contact inhibition IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016324 apical plasma membrane IDA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle has fewer parts of type Kupffers vesicle motile cilium, abnormal
Kupffers vesicle motile cilium decreased length , abnormal
Show

 ZFA:0000008 brain brain hydrocephalic , abnormal
brain malformed , abnormal
brain edematous , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
dorsal aorta blood vessel lumenization disrupted , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has fewer parts of type oligodendrocyte , abnormal
spinal cord has fewer parts of type radial glial cell , abnormal
Show

 ZFA:0000076 swim bladder swim bladder dysplastic , abnormal
Show

 ZFA:0000101 diencephalon diencephalon ventral region structure , abnormal
Show

 ZFA:0000105 epidermis epidermis cell-cell junction decreased amount , abnormal
epidermis actin cytoskeleton structure , abnormal
Show

 ZFA:0000107 eye eye decreased distance eye , abnormal
eye fused with eye , abnormal
eye malformed , abnormal
Show

 ZFA:0000133 neural rod neural rod centrosome mislocalised , abnormal
neural rod axoneme irregular spatial pattern , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium patchy , abnormal
Show

 ZFA:0000152 retina retina morphology , abnormal
retina disorganized , abnormal
retina has fewer parts of type retinal rod cell , abnormal
Show

 ZFA:0000368 integument integument epidermal cell decreased area , abnormal
Show

 ZFA:0000938 central canal central canal increased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism posterior region curved , abnormal
whole organism semi-lethal (sensu genetics) , abnormal
Show

 ZFA:0001135 neural tube neural tube centrosome mislocalised , abnormal
Show

 ZFA:0001194 cranial neural crest cranial neural crest condensed , abnormal
Show

 ZFA:0009003 cranial neural crest cell cranial neural crest cell broadly articulated with cranial neural crest cell , abnormal
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 ZFA:0009004 trunk neural crest cell trunk neural crest cell shape , abnormal
trunk neural crest cell disorganized , abnormal
trunk neural crest cell broadly articulated with trunk neural crest cell , abnormal
trunk neural crest cell contact inhibition disrupted , abnormal
Show

 ZFA:0009076 oligodendrocyte oligodendrocyte loose , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell photoreceptor outer segment decreased length , abnormal
photoreceptor cell photoreceptor inner segment physical object quality , abnormal
Show

 ZFA:0009135 myelinating Schwann cell myelinating Schwann cell mislocalised , abnormal
myelinating Schwann cell loose , abnormal
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell lacks parts or has fewer parts of type eye photoreceptor cell photoreceptor outer segment, abnormal
eye photoreceptor cell apical region decreased length , abnormal
eye photoreceptor cell has fewer parts of type eye photoreceptor cell photoreceptor connecting cilium, abnormal
eye photoreceptor cell apical region decreased area , abnormal
eye photoreceptor cell establishment of apical/basal cell polarity decreased process quality , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation pericardium , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon decreased branchiness , abnormal
retinal ganglion cell collateral sprouting in absence of injury decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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