ENSG00000158769


Homo sapiens

Features
Gene ID: ENSG00000158769
  
Biological name :F11R
  
Synonyms : F11R / F11 receptor / Q9Y624
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 160995211
Gene end: 161021348
  
Corresponding Affymetrix probe sets: 221664_s_at (Human Genome U133 Plus 2.0 Array)   222354_at (Human Genome U133 Plus 2.0 Array)   223000_s_at (Human Genome U133 Plus 2.0 Array)   224097_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357005
Ensembl peptide - ENSP00000481591
Ensembl peptide - ENSP00000440812
NCBI entrez gene - 50848     See in Manteia.
OMIM - 605721
RefSeq - NM_016946
RefSeq Peptide - NP_058642
swissprot - A0A087WY82
swissprot - Q6FIB4
swissprot - Q9Y624
Ensembl - ENSG00000158769
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f11r.1ENSDARG00000017320Danio rerio
 f11r.2ENSDARG00000068114Danio rerio
 F11rENSMUSG00000038235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JAM3 / Q9BX67 / junctional adhesion molecule 3ENSG0000016608632
JAM2 / P57087 / junctional adhesion molecule 2ENSG0000015472132


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0031032 actomyosin structure organization IMP
 biological_processGO:0034260 negative regulation of GTPase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050892 intestinal absorption IMP
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0070830 bicellular tight junction assembly TAS
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090557 establishment of endothelial intestinal barrier IMP
 biological_processGO:0090559 regulation of membrane permeability IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction TAS
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036057 slit diaphragm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / complex / reaction
 ENSG00000005844 ITGAL / P20701 / integrin subunit alpha L  / reaction / complex
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / reaction / complex
 ENSG00000178184 PARD6G / Q9BYG4 / par-6 family cell polarity regulator gamma  / reaction / complex
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex / reaction
 ENSG00000148498 PARD3 / Q8TEW0 / par-3 family cell polarity regulator  / reaction / complex
 ENSG00000102981 PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha  / complex / reaction
 ENSG00000124171 PARD6B / Q9BYG5 / par-6 family cell polarity regulator beta  / reaction / complex






 

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