ENSG00000154721


Homo sapiens

Features
Gene ID: ENSG00000154721
  
Biological name :JAM2
  
Synonyms : JAM2 / junctional adhesion molecule 2 / P57087
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q21.3
Gene start: 25639272
Gene end: 25717562
  
Corresponding Affymetrix probe sets: 219213_at (Human Genome U133 Plus 2.0 Array)   229127_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000318416
Ensembl peptide - ENSP00000383376
Ensembl peptide - ENSP00000420419
Ensembl peptide - ENSP00000436801
NCBI entrez gene - 58494     See in Manteia.
OMIM - 606870
RefSeq - NM_001270407
RefSeq - NM_001270408
RefSeq - NM_021219
RefSeq Peptide - NP_001257336
RefSeq Peptide - NP_001257337
RefSeq Peptide - NP_067042
swissprot - P57087
swissprot - H0YEX9
Ensembl - ENSG00000154721
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jam2aENSDARG00000058996Danio rerio
 jam2bENSDARG00000079071Danio rerio
 JAM2ENSGALG00000015746Gallus gallus
 Jam2ENSMUSG00000053062Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JAM3 / Q9BX67 / junctional adhesion molecule 3ENSG0000016608631
F11R / Q9Y624 / F11 receptorENSG0000015876931


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0098609 cell-cell adhesion NAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / complex / reaction
 ENSG00000154721 JAM2 / P57087 / junctional adhesion molecule 2  / reaction / complex






 

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