ENSMUSG00000053062


Mus musculus

Features
Gene ID: ENSMUSG00000053062
  
Biological name :Jam2
  
Synonyms : Jam2 / Junctional adhesion molecule B / Q9JI59
  
Possible biological names infered from orthology : junctional adhesion molecule 2 / P57087
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 84774123
Gene end: 84825928
  
Corresponding Affymetrix probe sets: 10436666 (MoGene1.0st)   1419288_at (Mouse Genome 430 2.0 Array)   1431416_a_at (Mouse Genome 430 2.0 Array)   1431417_at (Mouse Genome 430 2.0 Array)   1436568_at (Mouse Genome 430 2.0 Array)   1449408_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096007
Ensembl peptide - ENSMUSP00000109833
NCBI entrez gene - 67374     See in Manteia.
MGI - MGI:1933820
RefSeq - XM_006523075
RefSeq - NM_023844
RefSeq Peptide - NP_076333
swissprot - Q9CWD9
swissprot - Q9JI59
Ensembl - ENSMUSG00000053062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jam2aENSDARG00000058996Danio rerio
 jam2bENSDARG00000079071Danio rerio
 JAM2ENSGALG00000015746Gallus gallus
 JAM2ENSG00000154721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jam3 / Q9D8B7 / Junctional adhesion molecule C / Q9BX67* / junctional adhesion molecule 3*ENSMUSG0000003199033
F11r / O88792 / Junctional adhesion molecule A / Q9Y624* / F11 receptor*ENSMUSG0000003823533


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0005387 immune system phenotype 
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Izumo1rtm1b(KOMP)Wtsi/Izumo1rtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm1b(KOMP)Wtsi/Rbrc

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031990 Jam3 / Q9D8B7 / Junctional adhesion molecule C / Q9BX67* / junctional adhesion molecule 3*  / reaction / complex
 ENSMUSG00000053062 Jam2 / Q9JI59 / Junctional adhesion molecule B / P57087* / junctional adhesion molecule 2*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000027009 Itga4 / integrin subunit alpha 4 / P13612*  / complex / reaction






 

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