MP:0000322 | increased granulocyte number | "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000439 | enlarged skull | |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0000917 | obstructive hydrocephaly | "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0001273 | decreased metastatic potential | |
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Allelic Composition: Cygbtm1Nka/Cygb+ Genetic Background: B6.Cg-Cygbtm1Nka
Allelic Composition: Jam3tm1.1Chav/Jam3tm1.2Chav,Tg(Cdh5-cre)7Mlia/? Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: B6.129-Jam3tm1.2Chav
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001511 | disheveled coat | "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001663 | abnormal digestive system physiology | "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
Allelic Composition: Jam3tm1Rha/Jam3tm1Rha,Tg(Tek-Jam3)1Maal/0 Genetic Background: B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal
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MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001917 | intraventricular hemorrhage | "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
Allelic Composition: Jam3tm1Rha/Jam3tm1Rha,Tg(Tek-Jam3)1Maal/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: B6.129-Jam3tm1.2Chav
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0002686 | globozoospermia | "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
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MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0004545 | enlarged esophagus | "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
Allelic Composition: Jam3tm1Rha/Jam3tm1Rha,Tg(Tek-Jam3)1Maal/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
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MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0009376 | abnormal manchette morphology | "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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MP:0009969 | abnormal cerebral cortex pyramidal cell morphology | "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm1Bbd/Kras+,Trp53tm1Brd/Trp53+,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/? Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Thrbtm1Few/Thrbtm1Few Genetic Background: involves: 129S4/SvJae
Allelic Composition: Jam3tm1Rha/Jam3tm1Rha Genetic Background: B6.129P2-Jam3tm1Rha
Allelic Composition: Jam3tm1Rha/Jam3tm1Rha,Tg(Tek-Jam3)1Maal/0 Genetic Background: B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: B6.129-Jam3tm1.2Chav
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Jam3tm1.2Chav/Jam3tm1.2Chav Genetic Background: B6.129-Jam3tm1.2Chav
Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J
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MP:0014185 | cerebellum atrophy | "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna] |
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Allelic Composition: Jam3tm1Rha/Jam3tm1Rha Genetic Background: B6.129P2-Jam3tm1Rha
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