ENSG00000154229


Homo sapiens

Features
Gene ID: ENSG00000154229
  
Biological name :PRKCA
  
Synonyms : P17252 / PRKCA / protein kinase C alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q24.2
Gene start: 66302636
Gene end: 66810743
  
Corresponding Affymetrix probe sets: 1560074_at (Human Genome U133 Plus 2.0 Array)   206923_at (Human Genome U133 Plus 2.0 Array)   213093_at (Human Genome U133 Plus 2.0 Array)   215194_at (Human Genome U133 Plus 2.0 Array)   215195_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000284384
Ensembl peptide - ENSP00000408695
Ensembl peptide - ENSP00000462087
NCBI entrez gene - 5578     See in Manteia.
OMIM - 176960
RefSeq - XM_017024841
RefSeq - XM_017024836
RefSeq - XM_017024837
RefSeq - XM_017024838
RefSeq - XM_017024839
RefSeq - XM_017024840
RefSeq - NM_002737
RefSeq Peptide - NP_002728
swissprot - J3KRN5
swissprot - L7RSM7
swissprot - J3KN97
swissprot - P17252
Ensembl - ENSG00000154229
  
Related genetic diseases (OMIM): 176960 - Pituitary tumor, invasive
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcaENSDARG00000115657Danio rerio
 PRKCAENSDARG00000099841Danio rerio
 PRKCAENSGALG00000025950Gallus gallus
 PrkcaENSMUSG00000050965Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCB / P05771 / protein kinase C betaENSG0000016650180
PRKCG / P05129 / protein kinase C gammaENSG0000012658372
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113244
PRKCH / P24723 / protein kinase C etaENSG0000002707541
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567541
PRKCD / Q05655 / protein kinase C deltaENSG0000016393240
PRKCI / P41743 / protein kinase C iotaENSG0000016355833
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760632
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522127
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220827
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702026
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851525
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420525
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034663  Classical Protein Kinase C alpha, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002159 desmosome assembly IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IMP
 biological_processGO:0035408 histone H3-T6 phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045651 positive regulation of macrophage differentiation ISS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045780 positive regulation of bone resorption ISS
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070555 response to interleukin-1 IMP
 biological_processGO:0090330 regulation of platelet aggregation IDA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0106071 positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:2000707 positive regulation of dense core granule biogenesis ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0035866 alphav-beta3 integrin-PKCalpha complex ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004697 protein kinase C activity ISS
 molecular_functionGO:0004698 calcium-dependent protein kinase C activity TAS
 molecular_functionGO:0005178 integrin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000186326 Q6ZS82 / RGS9BP / regulator of G protein signaling 9 binding protein  / reaction
 ENSG00000069966 GNB5 / O14775 / G protein subunit beta 5  / reaction
 ENSG00000154134 ROBO3 / Q96MS0 / roundabout guidance receptor 3  / complex / reaction
 ENSG00000176170 SPHK1 / Q9NYA1 / sphingosine kinase 1  / reaction
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction
 ENSG00000108370 RGS9 / O75916 / regulator of G protein signaling 9  / reaction
 ENSG00000173020 GRK2 / P25098 / G protein-coupled receptor kinase 2  / reaction
 ENSG00000102119 EMD / emerin / P50402  / reaction
 ENSG00000066044 ELAVL1 / Q15717 / ELAV like RNA binding protein 1  / reaction
 ENSG00000116266 O00186 / STXBP3 / syntaxin binding protein 3  / reaction
 ENSG00000103496 STX4 / Q12846 / syntaxin 4  / reaction
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / reaction / complex
 ENSG00000277443 MARCKS / P29966 / myristoylated alanine rich protein kinase C substrate  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / reaction / complex
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex






 

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