ENSG00000066044


Homo sapiens

Features
Gene ID: ENSG00000066044
  
Biological name :ELAVL1
  
Synonyms : ELAVL1 / ELAV like RNA binding protein 1 / Q15717
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 7958579
Gene end: 8005659
  
Corresponding Affymetrix probe sets: 201726_at (Human Genome U133 Plus 2.0 Array)   201727_s_at (Human Genome U133 Plus 2.0 Array)   227746_at (Human Genome U133 Plus 2.0 Array)   244660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471011
Ensembl peptide - ENSP00000472197
Ensembl peptide - ENSP00000385269
Ensembl peptide - ENSP00000470727
NCBI entrez gene - 1994     See in Manteia.
OMIM - 603466
RefSeq - NM_001419
RefSeq Peptide - NP_001410
swissprot - M0QZR9
swissprot - M0R055
swissprot - Q15717
Ensembl - ENSG00000066044
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elavl1aENSDARG00000038695Danio rerio
 elavl1bENSDARG00000101744Danio rerio
 ELAVL1ENSGALG00000000726Gallus gallus
 Elavl1ENSMUSG00000040028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELAVL2 / Q12926 / ELAV like RNA binding protein 2ENSG0000010710574
ELAVL4 / P26378 / ELAV like RNA binding protein 4ENSG0000016237472
ELAVL3 / Q14576 / ELAV like RNA binding protein 3ENSG0000019636169
RBMS2 / Q15434 / RNA binding motif single stranded interacting protein 2ENSG0000007606727
RBMS3 / Q6XE24 / RNA binding motif single stranded interacting protein 3ENSG0000014464227
RBMS1 / P29558 / RNA binding motif single stranded interacting protein 1ENSG0000015325026
PABPC4 / Q13310 / poly(A) binding protein cytoplasmic 4ENSG0000009062124
PUF60 / Q9UHX1 / poly(U) binding splicing factor 60ENSG0000017995023
Q4VXU2 / PABPC1L / poly(A) binding protein cytoplasmic 1 likeENSG0000010110423
P11940 / PABPC1 / poly(A) binding protein cytoplasmic 1ENSG0000007075622
PABPC3 / Q9H361 / poly(A) binding protein cytoplasmic 3ENSG0000015184622
P0CB38 / PABPC4L / poly(A) binding protein cytoplasmic 4 likeENSG0000025453516
PABPC5 / Q96DU9 / poly(A) binding protein cytoplasmic 5ENSG0000017474015
Q5JQF8 / PABPC1L2A / poly(A) binding protein cytoplasmic 1 like 2AENSG000001862881
Q5JQF8 / PABPC1L2B / poly(A) binding protein cytoplasmic 1 like 2BENSG000001843881


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002343  Paraneoplastic encephalomyelitis antigen
 IPR006548  Splicing factor ELAV/Hu
 IPR034775  Splicing factor ELAV/Hu, RNA recognition motif 1
 IPR034996  HuR, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0048255 mRNA stabilization IDA
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IGI
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IMP
 biological_processGO:2000036 regulation of stem cell population maintenance ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:1990904 ribonucleoprotein complex ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003729 mRNA binding TAS
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
HuR (ELAVL1) binds and stabilizes mRNA
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction






 

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