Manteia - Molecule gene

ENSMUSG00000040028

Mus musculus

Features

Gene ID:	ENSMUSG00000040028

Biological name :	Elavl1

Synonyms :	Elavl1 / ELAV-like protein 1 / P70372

Possible biological names infered from orthology :	ELAV like RNA binding protein 1 / Q15717

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	A1.1
Gene start:	4285382
Gene end:	4325413

Corresponding Affymetrix probe sets:	10576873 (MoGene1.0st) 1428653_x_at (Mouse Genome 430 2.0 Array) 1431037_a_at (Mouse Genome 430 2.0 Array) 1440464_at (Mouse Genome 430 2.0 Array) 1445521_at (Mouse Genome 430 2.0 Array) 1448151_at (Mouse Genome 430 2.0 Array) 1452858_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000096549 Ensembl peptide - ENSMUSP00000146866 NCBI entrez gene - 15568 See in Manteia. MGI - MGI:1100851 RefSeq - XM_006508698 RefSeq - NM_010485 RefSeq Peptide - NP_034615 swissprot - P70372 Ensembl - ENSMUSG00000040028

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
elavl1a	ENSDARG00000038695	Danio rerio
elavl1b	ENSDARG00000101744	Danio rerio
ELAVL1	ENSGALG00000000726	Gallus gallus
ELAVL1	ENSG00000066044	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Elavl2 / Q60899 / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA. / Q12926* / ELAV like RNA binding protein 2*	ENSMUSG00000008489	74
Elavl4 / Q61701 / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA. / P26378* / ELAV like RNA binding protein 4*	ENSMUSG00000028546	72
Elavl3 / Q60900 / ELAV-like protein 3 / Q14576* / ELAV like RNA binding protein 3*	ENSMUSG00000003410	68
Rbms3 / Q8BWL5 / RNA binding motif, single stranded interacting protein / Q6XE24* / RNA binding motif single stranded interacting protein 3*	ENSMUSG00000039607	27
Rbms1 / Q91W59 / RNA-binding motif, single-stranded-interacting protein 1 / P29558*	ENSMUSG00000026970	27
Pabpc4 / poly(A) binding protein, cytoplasmic 4 / Q13310*	ENSMUSG00000011257	24
Rbms2 / Q8VC70 / RNA-binding motif, single-stranded-interacting protein 2 / Q15434*	ENSMUSG00000040043	24
Pabpc1l / poly(A) binding protein, cytoplasmic 1-like / Q4VXU2*	ENSMUSG00000054582	23
Puf60 / Q3UEB3 / Poly(U)-binding-splicing factor PUF60 / Q9UHX1* / poly(U) binding splicing factor 60*	ENSMUSG00000002524	23
P29341 / Pabpc1 / Polyadenylate-binding protein 1	ENSMUSG00000022283	23
Pabpc6	ENSMUSG00000046173	22
Pabpc2 / P11940* / PABPC1* / poly(A) binding protein cytoplasmic 1*	ENSMUSG00000051732	21
Pabpc5 / poly(A) binding protein cytoplasmic 5 / Q96DU9*	ENSMUSG00000034732	16
Pabpc4l / poly(A) binding protein cytoplasmic 4 like / P0CB38*	ENSMUSG00000090919	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000504	RNA recognition motif domain
IPR002343	Paraneoplastic encephalomyelitis antigen
IPR006548	Splicing factor ELAV/Hu
IPR034775	Splicing factor ELAV/Hu, RNA recognition motif 1
IPR034996	HuR, RNA recognition motif 2
IPR035979	RNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0045727	positive regulation of translation	ISO
biological_process	GO:0048255	mRNA stabilization	ISO
biological_process	GO:0060965	negative regulation of gene silencing by miRNA	ISO
biological_process	GO:0070935	3"-UTR-mediated mRNA stabilization	ISS
biological_process	GO:2000036	regulation of stem cell population maintenance	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:1990904	ribonucleoprotein complex	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003723	RNA binding	ISO
molecular_function	GO:0003725	double-stranded RNA binding	ISO
molecular_function	GO:0003729	mRNA binding	IDA
molecular_function	GO:0003730	mRNA 3"-UTR binding	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017091	AU-rich element binding	ISS
molecular_function	GO:0019901	protein kinase binding	ISO
molecular_function	GO:0035925	mRNA 3"-UTR AU-rich region binding	ISS
molecular_function	GO:0042803	protein homodimerization activity	ISO

Pathways (from Reactome)

Pathway description

HuR (ELAVL1) binds and stabilizes mRNA

mRNA Splicing - Major Pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000108	midline facial cleft	"incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000316	cellular necrosis	"pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db,Rock1^tm1Leiw/Rock1^tm1Leiw Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000334	decreased granulocyte number	"fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000490	abnormal crypts of Lieberkuhn morphology	"malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
MP:0000495	abnormal colon morphology	"malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000511	abnormal intestinal mucosa morphology	"structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000566	synostosis	"osseous union of two bones that are not normally connected" [J:13049]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0000714	increased thymocyte number	"greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0001713	reduced trophoblast cell number	"fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0001715	placental labyrinth hypoplasia	"reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0001722	pale yolk sac	"bloodless yolk sac" [J:62571]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N) Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(tTA,CMV1-KIAA1549/BRAF,-EGFP)Gtm}/Gt(ROSA)26Sor⁺,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background:* involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(tTA,CMV1-KIAA1549/BRAF,-EGFP)Gtm}/Gt(ROSA)26Sor⁺,Tg(Fabp7-cre,-lacZ)3Gtm/0 Genetic Background:* involves: 129S6/SvEvTac * C57BL/6 * CBA
MP:0002007	increased sensitivity to gamma-irradiation	"increased incidence of cell death following high levels of gamma-irradiation" [J:51834]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
MP:0002044	colonic adenoma	"benign tumors of the large intestine" [J:38772]	Show Allelic Composition: Htt^tm5Mem/Htt^tm5Mem Genetic Background: STOCK Htt^tm5Mem/J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0002128	abnormal blood circulation	"failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db,Rock1^tm1Leiw/Rock1^tm1Leiw Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0003270	intestinal obstruction	"any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0003449	abnormal intestinal goblet cells	"malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0003658	abnormal capillaries	"malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]	Show Allelic Composition: Lepr^db/Lepr^db,Rock1^tm1Leiw/Rock1^tm1Leiw Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N
MP:0003710	abnormal physiological neovascularization	"anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lepr^db/Lepr^db,Rock1^tm1Leiw/Rock1^tm1Leiw Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N
MP:0003721	increased tumor growth/size	"greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0003850	abnormal thymocyte activation/response	"anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0004256	abnormal maternal decidual layer morphology	"anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0004259	small placenta	"reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0004560	abnormal chorionic plate morphology	"any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0004575	small limb buds	"reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004678	split xiphoid process	"the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Atas/Elavl1^tm1.1Atas,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0004918	abnormal negative T cell selection	"any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0004919	abnormal positive T cell selection	"any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bach2^m2Anu/Bach2^m2Anu Genetic Background: C57BL/6NCrlAnu-Bach2^m2Anu
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0006413	increased T cell apoptosis	"increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmp7^tm1.2Dgra/Bmp7^tm1.2Dgra Genetic Background: B6.Cg-Bmp7^tm1.2Dgra
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0008250	abnormal myeloid leukocyte morphology	"any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008617	increased circulating interleukin-12 level	"increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008735	increased susceptibility to endotoxin shock	"more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008783	decreased B cell apoptosis	"reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0008959	abnormal spongiotrophoblast cell morphology	"any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0009314	colon adenocarcinoma	"malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0009323	abnormal spleen development	"aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0009511	distended stomach	"an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010220	decreased T-helper 17 cell number	"reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]	Show Allelic Composition: Elavl1^tm1.1Atas/Elavl1^tm1.1Atas,Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010760	abnormal macrophage chemotaxis	"anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]	Show Allelic Composition: Elavl1^tm1.1Dkon/Elavl1^tm1.1Dkon,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: B6.129P2-Elavl1^tm1.1Dkon Lyz2^tm1(cre)Ifo
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺,Tspan12^tm1Wye/Tspan12⁺ Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0012099	decreased spongiotrophoblast size	"reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]	Show Allelic Composition: Bak1^tm1Thsn/Bak1^tm1Thsn,Bcl2l1^tm1Dlo/Bcl2l1⁺ Genetic Background: B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn
MP:0014078	small intestinal villus atrophy	"erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353]	Show Allelic Composition: Elavl1^tm1Thla/Elavl1^tm1Thla,Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021948	Prkcd / P28867 / protein kinase C, delta / Q05655*	/ reaction
ENSMUSG00000050965	Prkca / protein kinase C, alpha / P17252*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr