ENSMUSG00000054582


Mus musculus

Features
Gene ID: ENSMUSG00000054582
  
Biological name :Pabpc1l
  
Synonyms : Pabpc1l / poly(A) binding protein, cytoplasmic 1-like
  
Possible biological names infered from orthology : Q4VXU2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 164025450
Gene end: 164050538
  
Corresponding Affymetrix probe sets: 10478432 (MoGene1.0st)   1439913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096701
NCBI entrez gene - 381404     See in Manteia.
MGI - MGI:1922908
RefSeq - XM_017319072
RefSeq - NM_001114079
RefSeq - XM_006499827
RefSeq - XM_006499828
RefSeq - XM_006499825
RefSeq - XM_006499826
RefSeq Peptide - NP_001107551
swissprot - A2A5N3
Ensembl - ENSMUSG00000054582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pabpc1lENSDARG00000002597Danio rerio
 PABPC1LENSGALG00000004123Gallus gallus
 Q4VXU2ENSG00000101104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P29341 / Pabpc1 / Polyadenylate-binding protein 1 ENSMUSG0000002228363
Pabpc4 / poly(A) binding protein, cytoplasmic 4 / Q13310*ENSMUSG0000001125761
Pabpc6ENSMUSG0000004617358
Pabpc2 / P11940* / PABPC1* / poly(A) binding protein cytoplasmic 1*ENSMUSG0000005173257
Pabpc4l / poly(A) binding protein cytoplasmic 4 like / P0CB38*ENSMUSG0000009091935
Pabpc5 / poly(A) binding protein cytoplasmic 5 / Q96DU9*ENSMUSG0000003473234
Rbms1 / Q91W59 / RNA-binding motif, single-stranded-interacting protein 1 / P29558*ENSMUSG0000002697014
Elavl2 / Q60899 / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA. / Q12926* / ELAV like RNA binding protein 2*ENSMUSG0000000848913
Puf60 / Q3UEB3 / Poly(U)-binding-splicing factor PUF60 / Q9UHX1* / poly(U) binding splicing factor 60*ENSMUSG0000000252413
Elavl4 / Q61701 / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA. / P26378* / ELAV like RNA binding protein 4*ENSMUSG0000002854613
Rbms3 / Q8BWL5 / RNA binding motif, single stranded interacting protein / Q6XE24* / RNA binding motif single stranded interacting protein 3*ENSMUSG0000003960713
Elavl3 / Q60900 / ELAV-like protein 3 / Q14576* / ELAV like RNA binding protein 3*ENSMUSG0000000341012
Elavl1 / P70372 / ELAV-like protein 1 / Q15717* / ELAV like RNA binding protein 1*ENSMUSG0000004002812
Rbms2 / Q8VC70 / RNA-binding motif, single-stranded-interacting protein 2 / Q15434*ENSMUSG0000004004312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4
 IPR035979  RNA-binding domain superfamily
 IPR036053  PABC (PABP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006378 mRNA polyadenylation IMP
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IMP
 biological_processGO:0051647 nucleus localization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008143 poly(A) binding TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0011128 increased secondary ovarian follicle number "greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

 MP:0011701 decreased cumulus expansion "reduced ability of the ovarian cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna]
Show

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr