ENSMUSG00000011257


Mus musculus

Features
Gene ID: ENSMUSG00000011257
  
Biological name :Pabpc4
  
Synonyms : Pabpc4 / poly(A) binding protein, cytoplasmic 4
  
Possible biological names infered from orthology : Q13310
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 123262351
Gene end: 123298925
  
Corresponding Affymetrix probe sets: 10386543 (MoGene1.0st)   10386548 (MoGene1.0st)   10421917 (MoGene1.0st)   10507851 (MoGene1.0st)   1421046_a_at (Mouse Genome 430 2.0 Array)   1451296_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077794
Ensembl peptide - ENSMUSP00000101848
Ensembl peptide - ENSMUSP00000101850
Ensembl peptide - ENSMUSP00000139135
Ensembl peptide - ENSMUSP00000079070
NCBI entrez gene - 230721     See in Manteia.
MGI - MGI:2385206
RefSeq - XM_017320151
RefSeq - NM_130881
RefSeq - NM_148917
RefSeq - XM_006503020
RefSeq - XM_006503021
RefSeq - XM_006503022
RefSeq - XM_006503023
RefSeq - XM_006503024
RefSeq Peptide - NP_570951
RefSeq Peptide - NP_683717
swissprot - A3KFU5
swissprot - A3KFU8
swissprot - Q91YZ8
swissprot - Q6PHQ9
swissprot - V9GXG3
Ensembl - ENSMUSG00000011257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pabpc4ENSDARG00000059259Danio rerio
 ENSGALG00000003800Gallus gallus
 PABPC4ENSG00000090621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P29341 / Pabpc1 / Polyadenylate-binding protein 1 ENSMUSG0000002228375
Pabpc6ENSMUSG0000004617365
Pabpc2 / P11940* / PABPC1* / poly(A) binding protein cytoplasmic 1*ENSMUSG0000005173264
Pabpc1l / poly(A) binding protein, cytoplasmic 1-like / Q4VXU2*ENSMUSG0000005458256
Pabpc4l / poly(A) binding protein cytoplasmic 4 like / P0CB38*ENSMUSG0000009091938
Pabpc5 / poly(A) binding protein cytoplasmic 5 / Q96DU9*ENSMUSG0000003473236
Rbms1 / Q91W59 / RNA-binding motif, single-stranded-interacting protein 1 / P29558*ENSMUSG0000002697015
Rbms2 / Q8VC70 / RNA-binding motif, single-stranded-interacting protein 2 / Q15434*ENSMUSG0000004004314
Rbms3 / Q8BWL5 / RNA binding motif, single stranded interacting protein / Q6XE24* / RNA binding motif single stranded interacting protein 3*ENSMUSG0000003960714
Elavl3 / Q60900 / ELAV-like protein 3 / Q14576* / ELAV like RNA binding protein 3*ENSMUSG0000000341012
Elavl1 / P70372 / ELAV-like protein 1 / Q15717* / ELAV like RNA binding protein 1*ENSMUSG0000004002812
Puf60 / Q3UEB3 / Poly(U)-binding-splicing factor PUF60 / Q9UHX1* / poly(U) binding splicing factor 60*ENSMUSG0000000252412
Elavl2 / Q60899 / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA. / Q12926* / ELAV like RNA binding protein 2*ENSMUSG0000000848912
Elavl4 / Q61701 / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA. / P26378* / ELAV like RNA binding protein 4*ENSMUSG0000002854612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4
 IPR035979  RNA-binding domain superfamily
 IPR036053  PABC (PABP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0061515 myeloid cell development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010494 cytoplasmic stress granule ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0008143 poly(A) binding ISO
 molecular_functionGO:0008266 poly(U) RNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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