ENSDARG00000099841


Danio rerio

Features
Gene ID: ENSDARG00000099841
  
Biological name :PRKCA
  
Synonyms : PRKCA / si:ch1073-370j18.1 / si:ch73-374l24.1
  
Possible biological names infered from orthology : P17252 / protein kinase C alpha
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 56163276
Gene end: 56342119
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131870
Ensembl peptide - ENSDARP00000138087
Ensembl peptide - ENSDARP00000138256
swissprot - A0A0J9YJ54
swissprot - A0A0R4IPY3
swissprot - A0A0R4IUK0
ZFIN ID - ZDB-GENE-131121-412
ZFIN ID - ZDB-GENE-141216-6
Ensembl - ENSDARG00000099841
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKCAENSGALG00000025950Gallus gallus
 PRKCAENSG00000154229Homo sapiens
 PrkcaENSMUSG00000050965Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565784
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225474
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872370
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456164
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300841
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992841
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065139
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838238
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920838
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324338
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417338
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333230
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122530
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481027
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121926
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720526
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361226
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552225
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246024
si:ch211-195b13.1ENSDARG0000001662323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000052518 stx4 / syntaxin 4 / Stx4a* / P70452* / Q12846*  / reaction
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSDARG00000008803 marcksb / myristoylated alanine-rich protein kinase C substrate b / P29966* / MARCKS* / P26645* / Myristoylated alanine-rich C-kinase substrate * / myristoylated alanine rich protein kinase...  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr