ENSDARG00000043317


Danio rerio

Features
Gene ID: ENSDARG00000043317
  
Biological name :kita
  
Synonyms : kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
  
Possible biological names infered from orthology : KIT / KIT proto-oncogene receptor tyrosine kinase / Mast/stem cell growth factor receptor Kit / P05532 / P10721
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 22335511
Gene end: 22378401
  
Corresponding Affymetrix probe sets: Dr.2268.1.A1_at (Zebrafish Array)   Dr.8096.1.S1_at (Zebrafish Array)   NM_131053_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000099069
Ensembl peptide - ENSDARP00000024170
NCBI entrez gene - 30256     See in Manteia.
RefSeq - NM_131053
RefSeq Peptide - NP_571128
swissprot - B3DGS5
swissprot - Q8JFR5
ZFIN ID - ZDB-GENE-980526-464
Ensembl - ENSDARG00000043317
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KITENSGALG00000038634Gallus gallus
 KITENSG00000157404Homo sapiens
 KitENSMUSG00000005672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613354
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298637
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362436
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049433
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089732
kdrl / kinase insert domain receptor likeENSDARG0000010521530
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732129
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445329
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937128
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850327
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478223
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811523
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910523
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102722
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530521
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027263  Mast/stem cell growth factor receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0014831 gastro-intestinal system smooth muscle contraction IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038093 Fc receptor signaling pathway IEA
 biological_processGO:0038109 Kit signaling pathway IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048865 stem cell fate commitment IMP
 biological_processGO:0097324 melanocyte migration IMP
 biological_processGO:1902362 melanocyte apoptotic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton morphology , abnormal
pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000112 gut gut decreased contractility , abnormal
gut distended , abnormal
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 ZFA:0000277 scale scale melanocyte decreased amount , abnormal
scale iridophore increased amount , abnormal
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 ZFA:0001094 whole organism whole organism has fewer parts of type melanocyte , abnormal
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 ZFA:0001114 head head melanocyte absent , abnormal
head melanocyte mislocalised , abnormal
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 ZFA:0001115 trunk trunk melanophore stripe disorganized , abnormal
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 ZFA:0001136 hypodermis hypodermis xanthophore absent , abnormal
hypodermis melanocyte decreased amount , abnormal
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 ZFA:0001463 melanophore stripe melanophore stripe melanocyte decreased amount , abnormal
melanophore stripe irregular spatial pattern , abnormal
melanophore stripe broken , abnormal
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 ZFA:0005222 ventral larval melanophore stripe ventral larval melanophore stripe melanocyte decreased amount , abnormal
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 ZFA:0005223 lateral larval melanophore stripe lateral larval melanophore stripe melanocyte decreased amount , abnormal
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 ZFA:0009090 pigment cell pigment cell quality , abnormal
pigment cell irregular spatial pattern , abnormal
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 ZFA:0009091 melanocyte melanocyte quality , abnormal
melanocyte shape , abnormal
melanocyte spatial pattern , abnormal
melanocyte decreased size , abnormal
melanocyte decreased amount , abnormal
melanocyte morphology , abnormal
melanocyte irregular spatial pattern , abnormal
melanocyte circular , abnormal
melanocyte apoptotic , abnormal
melanocyte melanosome low saturation , abnormal
melanocyte mislocalised , abnormal
melanocyte absent , abnormal
melanocyte accumulation otic vesicle posterior_to, abnormal
melanocyte apoptotic process increased occurrence , abnormal
melanocyte regeneration decreased process quality , abnormal
melanocyte developmental pigmentation process quality , abnormal
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 ZFA:0009199 iridophore iridophore decreased amount , abnormal
iridophore increased amount , abnormal
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 ZFA:0009249 melanoblast melanoblast increased amount , abnormal
melanoblast aggregated , abnormal
melanoblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex / reaction
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000099841 PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*  / reaction / complex






 

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