ENSDARG00000100897


Danio rerio

Features
Gene ID: ENSDARG00000100897
  
Biological name :pdgfrb
  
Synonyms : pdgfrb / platelet-derived growth factor receptor, beta polypeptide
  
Possible biological names infered from orthology : P09619 / platelet derived growth factor receptor beta / platelet-derived growth factor receptor beta isoform 2
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 3186485
Gene end: 3268155
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000152459
Ensembl peptide - ENSDARP00000138883
NCBI entrez gene - 559529     See in Manteia.
RefSeq - NM_001190933
RefSeq Peptide - NP_001177862
swissprot - A0A0G2L2B8
ZFIN ID - ZDB-GENE-030805-2
Ensembl - ENSDARG00000100897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDGFRBENSGALG00000030613Gallus gallus
 P09619ENSG00000113721Homo sapiens
 PdgfrbENSMUSG00000024620Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049440
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298629
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331729
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613328
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732127
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362427
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445327
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937127
kdrl / kinase insert domain receptor likeENSDARG0000010521526
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850321
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102721
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910521
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811520
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478220
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119020
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001755 neural crest cell migration IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048702 embryonic neurocranium morphogenesis IGI
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0061300 cerebellum vasculature development IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased distribution , abnormal
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 ZFA:0001094 whole organism whole organism absent , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
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 ZFA:0005021 cerebellar central artery cerebellar central artery vascular associated smooth muscle cell decreased amount , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell amount , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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