ENSDARG00000104453


Danio rerio

Features
Gene ID: ENSDARG00000104453
  
Biological name :flt4
  
Synonyms : flt4 / fms-related tyrosine kinase 4
  
Possible biological names infered from orthology : P35916 / P35917 / Vascular endothelial growth factor receptor 3
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 15816509
Gene end: 15956921
  
Corresponding Affymetrix probe sets: Dr.8087.1.S1_at (Zebrafish Array)   NM_130945_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000156181
Ensembl peptide - ENSDARP00000133227
NCBI entrez gene - 30121     See in Manteia.
RefSeq - NM_130945
RefSeq - XM_009307792
RefSeq Peptide - NP_571020
swissprot - A0A0R4IFS9
ZFIN ID - ZDB-GENE-980526-326
Ensembl - ENSDARG00000104453
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FLT4ENSGALG00000005802Gallus gallus
 FLT4ENSG00000037280Homo sapiens
 Flt4ENSMUSG00000020357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732140
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937137
kdrl / kinase insert domain receptor likeENSDARG0000010521536
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613321
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089721
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049421
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331721
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362420
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298620
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811518
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478218
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102717
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910517
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530517
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119016
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009137  Vascular endothelial growth factor receptor 3 (VEGFR3)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased distribution , abnormal
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 ZFA:0000107 eye eye anatomical region edematous , abnormal
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 ZFA:0000114 heart heart anatomical region edematous , abnormal
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 ZFA:0000339 digestive system digestive system anatomical region edematous , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein vascular sprouts absent , abnormal
posterior cardinal vein vascular sprouts decreased amount , abnormal
posterior cardinal vein lacks parts or has fewer parts of type lymphangiogenic sprout , abnormal
posterior cardinal vein decreased amount , abnormal
posterior cardinal vein endothelial cell absent , abnormal
posterior cardinal vein lymphangiogenic sprout decreased amount , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel aplastic , abnormal
primordial hindbrain channel absent , abnormal
primordial hindbrain channel malformed , abnormal
primordial hindbrain channel vasculature development decreased occurrence , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein decreased length , abnormal
intersegmental vein decreased amount , abnormal
intersegmental vein absent , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery blood vessel endothelial cell decreased amount , abnormal
intersegmental artery increased amount , abnormal
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 ZFA:0001063 posterior caudal vein posterior caudal vein vascular sprouts decreased amount , abnormal
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 ZFA:0001115 trunk trunk lymph vasculature aplastic , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel angiogenesis process quality , abnormal
intersegmental vessel absent , abnormal
intersegmental vessel aplastic , abnormal
intersegmental vessel blood vessel endothelial cell decreased amount , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel dorsal region branchiness , ameliorated
intersegmental vessel vascular sprouts amount , ameliorated
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 ZFA:0001338 intestine intestine lymphangiogenesis decreased process quality , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature branchiness , abnormal
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 ZFA:0005034 parachordal vessel parachordal vessel absent , abnormal
parachordal vessel vasculature development decreased occurrence , abnormal
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 ZFA:0005108 facial lymphatic vessel facial lymphatic vessel lateral region decreased length , abnormal
facial lymphatic vessel lymphangiogenesis decreased process quality , abnormal
facial lymphatic vessel lymphangiogenic sprout aplastic , abnormal
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 ZFA:0005110 thoracic duct thoracic duct hypoplastic , abnormal
thoracic duct aplastic , abnormal
thoracic duct lymphangiogenesis decreased process quality , abnormal
thoracic duct absent , abnormal
thoracic duct decreased length , abnormal
thoracic duct lymph vessel development decreased occurrence , abnormal
thoracic duct malformed , abnormal
thoracic duct lymph vessel development process quality , abnormal
thoracic duct decreased amount , abnormal
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 ZFA:0005603 lymphangiogenic sprout lymphangiogenic sprout decreased amount , abnormal
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 ZFA:0005605 lymphangioblast cord lymphangioblast cord absent , abnormal
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 ZFA:0005837 lateral facial lymph vessel lateral facial lymph vessel truncated , abnormal
lateral facial lymph vessel lymphangiogenic sprout absent , abnormal
lateral facial lymph vessel closed , abnormal
lateral facial lymph vessel malformed , abnormal
lateral facial lymph vessel lymph vessel development process quality , abnormal
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 ZFA:0005838 otolithic lymph vessel otolithic lymph vessel absent , abnormal
otolithic lymph vessel lymph vessel development delayed , abnormal
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 ZFA:0009065 endothelial cell endothelial cell decreased amount , abnormal
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 ZFA:0009395 vascular lymphangioblast vascular lymphangioblast absent , abnormal
vascular lymphangioblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104453 flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *  / reaction / complex
 ENSDARG00000056624 vegfd / vascular endothelial growth factor D / O43915* / P97946*  / reaction / complex
 ENSDARG00000069640 vegfc / vascular endothelial growth factor c / P49767* / P97953*  / complex / reaction






 

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