ENSDARG00000056624


Danio rerio

Features
Gene ID: ENSDARG00000056624
  
Biological name :vegfd
  
Synonyms : vascular endothelial growth factor D / vegfd
  
Possible biological names infered from orthology : O43915 / P97946
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 29889828
Gene end: 29916607
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000073608
Ensembl peptide - ENSDARP00000121602
NCBI entrez gene - 678512     See in Manteia.
RefSeq - NM_001040178
RefSeq Peptide - NP_001035268
swissprot - Q208T6
ZFIN ID - ZDB-GENE-070810-6
Ensembl - ENSDARG00000056624
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFDENSGALG00000016558Gallus gallus
 VEGFDENSG00000165197Homo sapiens
 VegfdENSMUSG00000031380Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vegfc / vascular endothelial growth factor c / P49767* / P97953*ENSDARG0000006964028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001946 lymphangiogenesis IGI
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001061 intersegmental artery intersegmental artery branchiness , ameliorated
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0005108 facial lymphatic vessel facial lymphatic vessel lymphangiogenesis decreased process quality , abnormal
facial lymphatic vessel lymphangiogenic sprout aplastic , abnormal
facial lymphatic vessel lateral region decreased length , abnormal
facial lymphatic vessel lymphangiogenesis decreased occurrence , abnormal
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 ZFA:0005110 thoracic duct thoracic duct lymph vessel development decreased occurrence , abnormal
thoracic duct endothelial cell decreased amount , abnormal
thoracic duct decreased amount , exacerbated
thoracic duct lymph vessel development decreased occurrence , exacerbated
thoracic duct decreased amount , abnormal
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 ZFA:0005298 cranial lymph vessel cranial lymph vessel lymphangiogenesis decreased process quality , abnormal
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 ZFA:0005605 lymphangioblast cord lymphangioblast cord decreased amount , abnormal
lymphangioblast cord lymph vessel development decreased occurrence , abnormal
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 ZFA:0005837 lateral facial lymph vessel lateral facial lymph vessel endothelial cell decreased amount , abnormal
lateral facial lymph vessel endothelial cell decreased amount , exacerbated
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 ZFA:0005838 otolithic lymph vessel otolithic lymph vessel endothelial cell decreased amount , abnormal
otolithic lymph vessel endothelial cell decreased amount , exacerbated
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 ZFA:0005839 medial facial lymph vessel medial facial lymph vessel endothelial cell decreased amount , abnormal
medial facial lymph vessel endothelial cell decreased amount , exacerbated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSDARG00000056624 vegfd / vascular endothelial growth factor D / O43915* / P97946*  / complex
 ENSDARG00000104453 flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *  / reaction / complex






 

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