ENSMUSG00000031380


Mus musculus

Features
Gene ID: ENSMUSG00000031380
  
Biological name :Vegfd
  
Synonyms : P97946 / vascular endothelial growth factor D / Vegfd
  
Possible biological names infered from orthology : O43915
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 164373378
Gene end: 164402650
  
Corresponding Affymetrix probe sets: 10603099 (MoGene1.0st)   1438953_at (Mouse Genome 430 2.0 Array)   1438954_x_at (Mouse Genome 430 2.0 Array)   1449528_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033751
NCBI entrez gene - 14205     See in Manteia.
MGI - MGI:108037
RefSeq - XM_006528701
RefSeq - NM_001308489
RefSeq - NM_010216
RefSeq - XM_006528700
RefSeq Peptide - NP_001295418
RefSeq Peptide - NP_034346
swissprot - P97946
Ensembl - ENSMUSG00000031380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfdENSDARG00000056624Danio rerio
 VEGFDENSGALG00000016558Gallus gallus
 VEGFDENSG00000165197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vegfc / P97953 / vascular endothelial growth factor C / P49767*ENSMUSG0000003152030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IBA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vegfdtm1Mach/Vegfdtm1Mach,Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

Allelic Composition: Vegfdtm1Mach/Y
Genetic Background: involves: 129S1/Sv

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Vegfdtm1Mach/Vegfdtm1Mach,Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020357 Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000031380 Vegfd / P97946 / vascular endothelial growth factor D / O43915*  / complex






 

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