ENSG00000165197


Homo sapiens

Features
Gene ID: ENSG00000165197
  
Biological name :VEGFD
  
Synonyms : O43915 / vascular endothelial growth factor D / VEGFD
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p22.2
Gene start: 15345591
Gene end: 15384376
  
Corresponding Affymetrix probe sets: 206742_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297904
NCBI entrez gene - 2277     See in Manteia.
OMIM - 300091
RefSeq - NM_004469
RefSeq Peptide - NP_004460
swissprot - O43915
Ensembl - ENSG00000165197
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfdENSDARG00000056624Danio rerio
 VEGFDENSGALG00000016558Gallus gallus
 VegfdENSMUSG00000031380Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VEGFC / P49767 / vascular endothelial growth factor CENSG0000015063031


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IDA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding TAS
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000037280 FLT4 / P35916 / fms related tyrosine kinase 4  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000165197 VEGFD / O43915 / vascular endothelial growth factor D  / complex






 

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