ENSG00000150630


Homo sapiens

Features
Gene ID: ENSG00000150630
  
Biological name :VEGFC
  
Synonyms : P49767 / vascular endothelial growth factor C / VEGFC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q34.3
Gene start: 176683538
Gene end: 176792727
  
Corresponding Affymetrix probe sets: 209946_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480043
NCBI entrez gene - 7424     See in Manteia.
OMIM - 601528
RefSeq - NM_005429
RefSeq Peptide - NP_005420
swissprot - P49767
Ensembl - ENSG00000150630
  
Related genetic diseases (OMIM): 615907 - Lymphedema, hereditary, ID, 615907
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfcENSDARG00000069640Danio rerio
 VEGFCENSGALG00000010847Gallus gallus
 VegfcENSMUSG00000031520Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VEGFD / O43915 / vascular endothelial growth factor DENSG0000016519726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR004153  CXCXC repeat
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006929 substrate-dependent cell migration TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IDA
 biological_processGO:1901492 positive regulation of lymphangiogenesis IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000034 Hydrocele 
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 HP:0001004 Lymphedema 
Show

 HP:0003828 Variable expressivity 
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 HP:0100797 Toenail dysplasia "An abnormality of the development of the toenails." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000037280 FLT4 / P35916 / fms related tyrosine kinase 4  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000150630 VEGFC / P49767 / vascular endothelial growth factor C  / complex






 

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