ENSMUSG00000031520


Mus musculus

Features
Gene ID: ENSMUSG00000031520
  
Biological name :Vegfc
  
Synonyms : P97953 / vascular endothelial growth factor C / Vegfc
  
Possible biological names infered from orthology : P49767
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.3
Gene start: 54077606
Gene end: 54187096
  
Corresponding Affymetrix probe sets: 10571788 (MoGene1.0st)   1419417_at (Mouse Genome 430 2.0 Array)   1439766_x_at (Mouse Genome 430 2.0 Array)   1440739_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033919
Ensembl peptide - ENSMUSP00000148210
NCBI entrez gene - 22341     See in Manteia.
MGI - MGI:109124
RefSeq - NM_009506
RefSeq Peptide - NP_033532
swissprot - P97953
Ensembl - ENSMUSG00000031520
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfcENSDARG00000069640Danio rerio
 VEGFCENSGALG00000010847Gallus gallus
 VEGFCENSG00000150630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vegfd / P97946 / vascular endothelial growth factor D / O43915*ENSMUSG0000003138026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR004153  CXCXC repeat
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IDA
 biological_processGO:0002052 positive regulation of neuroblast proliferation ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis ISO
 biological_processGO:1901492 positive regulation of lymphangiogenesis IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042056 chemoattractant activity ISO
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

Allelic Composition: Vegfdtm1Mach/Vegfdtm1Mach,Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfdtm1Mach/Vegfdtm1Mach,Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
Show

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0004106 lymphatic vessel hyperplasia "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic Background: involves: 129 * C57BL/6J

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Vegfdtm1Mach/Vegfdtm1Mach,Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfctm1Ali/Vegfctm1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010194 absent lymphatic vessels "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
Show

Allelic Composition: Rereom/RereGt(PTO26)1Byg
Genetic Background: involves: 129P2/OlaHsd * BTBR * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020357 Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000031520 Vegfc / P97953 / vascular endothelial growth factor C / P49767*  / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction






 

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