ENSDARG00000069640


Danio rerio

Features
Gene ID: ENSDARG00000069640
  
Biological name :vegfc
  
Synonyms : vascular endothelial growth factor c / vegfc
  
Possible biological names infered from orthology : P49767 / P97953
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 38850830
Gene end: 38908197
  
Corresponding Affymetrix probe sets: Dr.26450.1.S1_at (Zebrafish Array)   NM_205734_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000092263
Ensembl peptide - ENSDARP00000113916
NCBI entrez gene - 403049     See in Manteia.
RefSeq - NM_205734
RefSeq Peptide - NP_991297
swissprot - F6P2I4
swissprot - Q7T3I6
ZFIN ID - ZDB-GENE-040303-4
Ensembl - ENSDARG00000069640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VEGFCENSGALG00000010847Gallus gallus
 VEGFCENSG00000150630Homo sapiens
 VegfcENSMUSG00000031520Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vegfd / vascular endothelial growth factor D / O43915* / P97946*ENSDARG0000005662419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR004153  CXCXC repeat
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IGI
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0036303 lymph vessel morphogenesis IMP
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IGI
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IGI
 biological_processGO:0048514 blood vessel morphogenesis IGI
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 biological_processGO:0060855 venous endothelial cell migration involved in lymph vessel development IMP
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IGI
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0043185 vascular endothelial growth factor receptor 3 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000005 artery artery aplastic , abnormal
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 ZFA:0000006 ball ball edematous , abnormal
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 ZFA:0000107 eye eye anatomical region edematous , abnormal
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 ZFA:0000114 heart heart anatomical region edematous , abnormal
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 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelial cell decreased amount , abnormal
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 ZFA:0000339 digestive system digestive system anatomical region edematous , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein vascular sprouts decreased amount , abnormal
posterior cardinal vein decreased distribution , abnormal
posterior cardinal vein lacks parts or has fewer parts of type lymphangiogenic sprout , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel absent , abnormal
primordial hindbrain channel aplastic , abnormal
primordial hindbrain channel blood vessel development decreased occurrence , abnormal
primordial hindbrain channel malformed , abnormal
primordial hindbrain channel vasculature development decreased occurrence , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein decreased amount , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery increased amount , abnormal
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 ZFA:0001115 trunk trunk lymph vasculature aplastic , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature lymphatic system decreased functionality , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel absent , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel aplastic , abnormal
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 ZFA:0001338 intestine intestine lymphangiogenesis decreased process quality , abnormal
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 ZFA:0005105 lymph vasculature lymph vasculature absent , abnormal
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 ZFA:0005108 facial lymphatic vessel facial lymphatic vessel lymphangiogenesis decreased process quality , abnormal
facial lymphatic vessel lymphangiogenesis decreased occurrence , abnormal
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct decreased length , abnormal
thoracic duct aplastic , abnormal
thoracic duct decreased amount , abnormal
thoracic duct lymph vessel development decreased occurrence , abnormal
thoracic duct lymphangiogenesis decreased process quality , abnormal
thoracic duct malformed , abnormal
thoracic duct lymph vessel development process quality , abnormal
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 ZFA:0005258 lymph vessel endothelium lymph vessel endothelium endothelial cell decreased amount , abnormal
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 ZFA:0005603 lymphangiogenic sprout lymphangiogenic sprout decreased amount , abnormal
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 ZFA:0005605 lymphangioblast cord lymphangioblast cord absent , abnormal
lymphangioblast cord lymphangioblast decreased amount , abnormal
lymphangioblast cord lymph vessel development decreased occurrence , abnormal
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 ZFA:0005837 lateral facial lymph vessel lateral facial lymph vessel truncated , abnormal
lateral facial lymph vessel lymphangiogenic sprout absent , abnormal
lateral facial lymph vessel closed , abnormal
lateral facial lymph vessel malformed , abnormal
lateral facial lymph vessel lymph vessel development process quality , abnormal
lateral facial lymph vessel endothelial cell decreased amount , abnormal
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 ZFA:0005838 otolithic lymph vessel otolithic lymph vessel absent , abnormal
otolithic lymph vessel endothelial cell decreased amount , abnormal
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 ZFA:0005839 medial facial lymph vessel medial facial lymph vessel endothelial cell decreased amount , abnormal
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 ZFA:0009395 vascular lymphangioblast vascular lymphangioblast absent , abnormal
vascular lymphangioblast cellular motility , abnormal
vascular lymphangioblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000069640 vegfc / vascular endothelial growth factor c / P49767* / P97953*  / complex
 ENSDARG00000104453 flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *  / reaction / complex






 

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