ENSMUSG00000062960


Mus musculus

Features
Gene ID: ENSMUSG00000062960
  
Biological name :Kdr
  
Synonyms : Kdr / kinase insert domain receptor
  
Possible biological names infered from orthology : P35968
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 75932827
Gene end: 75978458
  
Corresponding Affymetrix probe sets: 10530692 (MoGene1.0st)   1449379_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109144
NCBI entrez gene - 16542     See in Manteia.
MGI - MGI:96683
RefSeq - NM_010612
RefSeq - XM_011240817
RefSeq Peptide - NP_034742
swissprot - Q8VCD0
Ensembl - ENSMUSG00000062960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdrENSDARG00000017321Danio rerio
 KDRENSGALG00000013907Gallus gallus
 KDRENSG00000128052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035742
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964842
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923122
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567221
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462121
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462021
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281719
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156519
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084919
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425219
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532018
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009136  Vascular endothelial growth factor receptor 2 (VEGFR2)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Kdrtm1.1Eia/Kdrtm1.1Eia
Genetic Background: B6.129P2-Kdrtm1.1Eia

Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0000263 absent organized vascular network "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: Not Specified

Allelic Composition: Kdrtm1.1Msh/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * B6.129-Kdrtm1Jrt/J * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Kdrtm1Ykub/Kdrtm1Ykub
Genetic Background: Not Specified

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Kdrtm1.1Msh/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd

Allelic Composition: Kdrtm1.2Jamb/Kdrtm1.2Jamb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kdrtm1.1Msh/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kdrtm1Jrt/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * B6.129-Kdrtm1Jrt/J * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flt1tm2Msh/Flt1+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kdrtm2.1Msh/Kdrtm2.1Msh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Kdrtm1.1Vlcg/Kdrtm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Ykub/Kdrtm1Ykub
Genetic Background: Not Specified

Allelic Composition: Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dnm1tm2.1Pdc/Dnm1tm2.1Pdc,Dnm2tm1.1Pdc/Dnm2tm1.1Pdc,Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

Allelic Composition: Kdrtm2Sato/Kdrtm2Sato,Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003543 abnormal vascular endothelial cell differentiation "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Flt1tm2Msh/Flt1+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Flt1tm2Msh/Flt1+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Flt1tm2Msh/Flt1tm2Msh,Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004106 lymphatic vessel hyperplasia "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Kdrtm1Ykub/Kdrtm1Ykub
Genetic Background: Not Specified

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * B6.129-Kdrtm1Jrt/J * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Kdrtm1Jrt/Kdr+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * B6.129-Kdrtm1Jrt/J * C57BL/6J

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0006338 abnormal second branchial arch morphology "anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010196 abnormal lymphatic vessel smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue that encompasses the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010200 enlarged lymphatic vessel "increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Kdrtm1Ykub/Kdrtm1Ykub
Genetic Background: Not Specified

 MP:0010642 absent third branchial arch "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010643 absent fourth branchial arch "absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010939 abnormal mandibular prominence morphology 
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Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptpn1tm2Bbk/Ptpn1tm2Bbk,Ptpn2tm1.1Ttig/Ptpn2tm1.1Ttig,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Kdrtm1.1Eia/Kdrtm1.1Eia
Genetic Background: B6.129P2-Kdrtm1.1Eia

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kdrtm1.1Msh/Kdrtm1.1Msh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Flt1tm2Msh/Flt1+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012756 impaired cranial neural crest cell differentiation "abnormal or arrest of differentiation or patterning of the cranial neural crest cells" [MGI:anna]
Show

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
Show

Allelic Composition: Kdrorv/Kdrorv
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002602 Axl / Q00993 / AXL receptor tyrosine kinase / P30530*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000020312 Shc2 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / SHC adaptor protein 2*  / complex / reaction
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex / reaction
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / complex / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / reaction / complex
 ENSMUSG00000028071 Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000031520 Vegfc / P97953 / vascular endothelial growth factor C / P49767*  / complex / reaction
 ENSMUSG00000031380 Vegfd / P97946 / vascular endothelial growth factor D / O43915*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / reaction / complex
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000028763 Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction / complex
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex






 

1 s.

 
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