ENSMUSG00000024621


Mus musculus

Features
Gene ID: ENSMUSG00000024621
  
Biological name :Csf1r
  
Synonyms : Csf1r / Macrophage colony-stimulating factor 1 receptor / P09581
  
Possible biological names infered from orthology : colony stimulating factor 1 receptor / P07333
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 61105572
Gene end: 61132149
  
Corresponding Affymetrix probe sets: 10456071 (MoGene1.0st)   1419872_at (Mouse Genome 430 2.0 Array)   1419873_s_at (Mouse Genome 430 2.0 Array)   1423593_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025523
Ensembl peptide - ENSMUSP00000110923
NCBI entrez gene - 12978     See in Manteia.
MGI - MGI:1339758
RefSeq - XM_017317810
RefSeq - NM_001037859
RefSeq - XM_006525584
RefSeq - XM_006525585
RefSeq - XM_006525586
RefSeq Peptide - NP_001032948
swissprot - P09581
swissprot - Q0P635
Ensembl - ENSMUSG00000024621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csf1raENSDARG00000102986Danio rerio
 csf1rbENSDARG00000053624Danio rerio
 CSF1RENSGALG00000005725Gallus gallus
 CSF1RENSG00000182578Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567237
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462034
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923132
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035730
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281730
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296029
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964829
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156523
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084923
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425223
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532022
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR030658  Macrophage colony-stimulating factor 1 receptor
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISO
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031529 ruffle organization IMP
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IMP
 biological_processGO:0038145 macrophage colony-stimulating factor signaling pathway IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045124 regulation of bone resorption ISS
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 biological_processGO:2000147 positive regulation of cell motility IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:1990682 CSF1-CSF1R complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IDA
 molecular_functionGO:0005011 macrophage colony-stimulating factor receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0019955 cytokine binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0000064 failure of secondary bone resorption "inability of osteoclasts to degrade the organic and inorganic phases of bone by absorption" [J:67040, J:61295]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000440 domed skull 
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0008753 abnormal osteocyte morphology "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0010047 axonal spheroids "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: involves: 129X1/SvJ * C3Heb/FeJ * C57BL/6J

 MP:0010892 increased oligodendrocyte progenitor number "greater number of cells that differentiate into a type of glial cell in the central nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0010970 abnormal compact bone lamellar structure "any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

 MP:0030188 round snout "appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0030487 abnormal osteocyte dendritic process morphology "any structural anomaly of the long, slender cytoplasmic processes by which mature osteocytes communicate with one another, receive mechanosensory signals and participate in the regulation of bone turnover; these processes radiate from the osteocyte cell body, run along narrow canaliculi, and are linked to other neighboring osteocytes processes by gap junctions, as well as to cytoplasmic processes of osteoblasts and bone lining cells on the bone surface" [https://www.hindawi.com/journals/bmri/2015/421746/, PMID:24419319]
Show

Allelic Composition: Csf1rtm1Ers/Csf1rtm1Ers
Genetic Background: FVB.129X1-Csf1rtm1Ers

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020592 Sdc1 / P18828 / syndecan 1 / P18827*  / complex
 ENSMUSG00000014599 Csf1 / P07141 / Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1 / P09603* / colony stimulating factor 1*  / complex
 ENSMUSG00000031750 Il34 / Q8R1R4 / Interleukin-34 / Q6ZMJ4*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr