Manteia - Molecule gene

ENSMUSG00000014599

Mus musculus

Features

Gene ID:	ENSMUSG00000014599

Biological name :	Csf1

Synonyms :	Csf1 / Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1 / P07141

Possible biological names infered from orthology :	colony stimulating factor 1 / P09603

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	F2.3
Gene start:	107741048
Gene end:	107760469

Corresponding Affymetrix probe sets:	10501164 (MoGene1.0st) 1425154_a_at (Mouse Genome 430 2.0 Array) 1425155_x_at (Mouse Genome 430 2.0 Array) 1448914_a_at (Mouse Genome 430 2.0 Array) 1460220_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000115480 Ensembl peptide - ENSMUSP00000113617 Ensembl peptide - ENSMUSP00000119553 Ensembl peptide - ENSMUSP00000014743 Ensembl peptide - ENSMUSP00000112832 Ensembl peptide - ENSMUSP00000113136 NCBI entrez gene - 12977 See in Manteia. MGI - MGI:1339753 RefSeq - NM_007778 RefSeq - NM_001113529 RefSeq - NM_001113530 RefSeq Peptide - NP_001107001 RefSeq Peptide - NP_031804 RefSeq Peptide - NP_001107002 swissprot - P07141 swissprot - D3YTW1 swissprot - D3Z090 swissprot - F6RNW8 Ensembl - ENSMUSG00000014599

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CSF1	ENSGALG00000033854	Gallus gallus
CSF1	ENSG00000184371	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR008001	Macrophage colony stimulating factor-1
IPR009079	Four-helical cytokine-like, core

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001954	positive regulation of cell-matrix adhesion	IGI
biological_process	GO:0002158	osteoclast proliferation	IDA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0003006	developmental process involved in reproduction	IMP
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO
biological_process	GO:0008284	positive regulation of cell proliferation	ISO
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010628	positive regulation of gene expression	ISO
biological_process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO
biological_process	GO:0010759	positive regulation of macrophage chemotaxis	ISO
biological_process	GO:0030278	regulation of ossification	IMP
biological_process	GO:0030316	osteoclast differentiation	ISO
biological_process	GO:0030335	positive regulation of cell migration	IGI
biological_process	GO:0032270	positive regulation of cellular protein metabolic process	ISO
biological_process	GO:0032946	positive regulation of mononuclear cell proliferation	ISO
biological_process	GO:0038145	macrophage colony-stimulating factor signaling pathway	IDA
biological_process	GO:0040018	positive regulation of multicellular organism growth	IMP
biological_process	GO:0042488	positive regulation of odontogenesis of dentin-containing tooth	IMP
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0045651	positive regulation of macrophage differentiation	ISO
biological_process	GO:0045657	positive regulation of monocyte differentiation	IMP
biological_process	GO:0045672	positive regulation of osteoclast differentiation	ISO
biological_process	GO:0045860	positive regulation of protein kinase activity	IGI
biological_process	GO:0046579	positive regulation of Ras protein signal transduction	IDA
biological_process	GO:0048873	homeostasis of number of cells within a tissue	IMP
biological_process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP
biological_process	GO:0060611	mammary gland fat development	IMP
biological_process	GO:0060763	mammary duct terminal end bud growth	IMP
biological_process	GO:1902228	positive regulation of macrophage colony-stimulating factor signaling pathway	ISO
biological_process	GO:1904141	positive regulation of microglial cell migration	ISO
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	ISO
cellular_component	GO:1990682	CSF1-CSF1R complex	IDA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0005157	macrophage colony-stimulating factor receptor binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008083	growth factor activity	IEA
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IPI

Pathways (from Reactome)

Pathway description

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Other interleukin signaling

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000061	fragile skeleton	"easily damaged or broken bones" [J:14208]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000065	abnormal bone marrow cavities	"absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0000067	osteopetrosis	"excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000121	failure of tooth eruption	"inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000124	absent teeth	"missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0000125	absent incisors	"missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000136	abnormal microglial cell morphology	"anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000198	hypophosphatemia	"abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000440	domed skull		Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0000628	abnormal mammary gland development	"aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0000662	abnormal branching of the mammary ductal tree	"anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000711	thymic cortex hypoplasia	"reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mpz^tm1Msch/Mpz⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0000954	reduced oligodendrocyte progenitor number	"fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001130	abnormal ovarian folliculogenesis	"atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0001377	abnormal copulation	"reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001380	male reduced copulation without impotence	"males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Hoxd8^tm1Jdes/Hoxd8⁺ Genetic Background: involves: 129S2/SvPas * FVB
MP:0001562	abnormal circulating calcium level	"anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001729	impaired implantation	"impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol,Ccr2^tm1Mae/Ccr2^tm1Mae Genetic Background: B6.129-Ccr2^tm1Mae Ccl2^tm1Rol
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001862	interstitial pneumonia	"disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001882	abnormal lactation	"atypical production of milk from the mammary gland" [J:51296]	Show Allelic Composition: Apc^Min/Apc⁺,Hp^tm1Skl/Hp^tm1Skl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv
MP:0002356	abnormal spleen red pulp morphology	"anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Snai2^tm2Grid/Snai2^tm2Grid Genetic Background: involves: 129S1/Sv Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0002673	abnormal sperm count	"increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002682	reduced number of mature ovarian follicles	"fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002872	polycythemia	"an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0003329	amyloid beta deposits		Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0003355	reduced ovulation	"reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0003357	impaired granulosa cell differentiation	"atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0003408	increased width of hypertrophic chondrocyte zone	"increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0003572	abnormal uterus development	"abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0003795	abnormal bone structure		Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004235	abnormal masseter muscle morphology	"any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004698	abnormal thyroid parafollicular C-cells	"any structural anomaly of the calcitonin-producing C-cells which are derived from the ultimobranchial body (a sac-like structure emanating from the neural crest) and constitute the minor component of the thyroid gland" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0004738	abnormal brainstem auditory evoked potential	"anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004742	abnormal vestibular system physiology	"any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004851	increased testis weight	"greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004884	abnormal testicular physiology	"anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0004983	abnormal osteoclast cell number	"deviation from the average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004986	abnormal osteoblast morphology	"any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004993	decreased bone resorption	"reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Csf1^op/Csf1^op Genetic Background: involves: 129P2/OlaHsd * C3HeB/Fe * C57BL/6
MP:0005362	abnormal Langerhans cell physiology	"atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0005422	osteosclerosis	"abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005605	increased bone mass	"an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005671	response to transplant	"the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]	Show Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Rag2^tm1.1Flv/Rag2^tm1.1Flv,Tg(SIRPA)1Flv/0,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac Allelic Composition: Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv},Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv},Il2rg^tm1.1Flv/Il2rg^tm1.1Flv,Rag2^tm1.1Flv/Rag2^tm1.1Flv,Tg(SIRPA)1Flv/0,Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0006270	abnormal mammary gland growth during lactation	"anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0006398	increased long bone epiphyseal plate size	"greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0008114	abnormal Kupffer cell morphology	"any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0008117	abnormal Langerhans cell morphology	"any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0008118	absent Langerhans cell	"absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0008242	abnormal perivascular macrophage morphology	"any structural anomaly of macrophages that line the small blood vessels" [PMID:16322748]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0008250	abnormal myeloid leukocyte morphology	"any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0008753	abnormal osteocyte morphology	"any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0008828	abnormal lymph node cell ratio	"deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0008871	abnormal ovarian follicle number	"abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0008917	abnormal oligodendrocyte physiology	"any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0009006	prolonged estrous cycle	"increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0009013	abnormal proestrus	"any anomaly or aberrant timing of the first phase of the estrous cycle which begins when a new batch of eggs reach maturity within ovarian follicles that are ripe and large; external examination of the female usually shows a bloated vulva with an open vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0009090	myometrium hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0009091	endometrium hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0009325	necrospermia	"condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0009333	abnormal splenocyte physiology	"any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0009505	abnormal mammary gland lobule morphology	"any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0009506	abnormal mammary gland alveolus morphology	"any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0009647	decreased fertilization frequency	"he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0009808	reduced oligodendrocyte number	"significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op,Galc^twi/Galc^twi Genetic Background: involves: C3HeB/Fe * C57BL/6J * CE/J
MP:0009971	decreased hippocampus pyramidal cell number	"decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0010748	abnormal visual evoked potential	"anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0010872	increased trabecular bone mass	"greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0010998	pulmonary alveolar proteinosis	"abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Csf1^op/Csf1^op,Csf2^tm1Ard/Csf2^tm1Ard Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0011129	decreased secondary ovarian follicle number	"fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0011165	abnormal tooth root development	"aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0011711	decreased osteoblast differentiation		Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0011966	abnormal auditory brainstem response waveform shape	"any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6;C3Fe a/a-Csf1^op/J
MP:0013586	thymus medulla atrophy	"acquired diminution of the inner area of thymus lobules associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: B6C3Fe a/a-Csf1^op/J
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030188	round snout	"appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]	Show Allelic Composition: Csf1^op/Csf1^op Genetic Background: C57BL/6J-Csf1^op
MP:0030451	abnormal dentin mineralization	"anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030479	increased osteocyte apoptosis	"increase in the number of osteocytes undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030484	abnormal osteocyte lacuna morphology	"any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030487	abnormal osteocyte dendritic process morphology	"any structural anomaly of the long, slender cytoplasmic processes by which mature osteocytes communicate with one another, receive mechanosensory signals and participate in the regulation of bone turnover; these processes radiate from the osteocyte cell body, run along narrow canaliculi, and are linked to other neighboring osteocytes processes by gap junctions, as well as to cytoplasmic processes of osteoblasts and bone lining cells on the bone surface" [https://www.hindawi.com/journals/bmri/2015/421746/, PMID:24419319]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030506	abnormal dental follicle morphology	"any structural anomaly of the loose ectomesenchyme-derived connective tissue sac that surrounds the enamel organ and the dental papilla of the developing tooth germ before eruption; it is believed that this tissue contains stem cells and lineage-committed progenitor cells or precursor cells for cementoblasts, periodontal ligament (PDL) cells and osteoblasts; dental follicle cells form the PDL by differentiating into PDL fibroblasts that secrete collagen and interact with fibers on the surface of adjacent bone and cementum" [PMID:21035344]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0030543	abnormal predentin morphology	"any structural anomaly of the initial type I collagen-rich unmineralized extracellular matrix synthesized and secreted by odontoblasts and located at the dentin-pulp interface; predentin is converted to dentin when hydroxyapatite crystals are deposited on the predentin" [https://books.google.com/books?isbn=0470958332]	Show Allelic Composition: Csf1^tm1.2Sabw/Csf1^tm1.2Sabw Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031750	Il34 / Q8R1R4 / Interleukin-34 / Q6ZMJ4*	/ complex / reaction
ENSMUSG00000024621	Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*	/ complex

0 s.

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