ENSMUSG00000031750


Mus musculus

Features
Gene ID: ENSMUSG00000031750
  
Biological name :Il34
  
Synonyms : Il34 / Interleukin-34 / Q8R1R4
  
Possible biological names infered from orthology : Q6ZMJ4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 110741829
Gene end: 110805924
  
Corresponding Affymetrix probe sets: 10581664 (MoGene1.0st)   1431920_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076120
Ensembl peptide - ENSMUSP00000114398
NCBI entrez gene - 76527     See in Manteia.
MGI - MGI:1923777
RefSeq - XM_011248544
RefSeq - NM_001135100
RefSeq - NM_029646
RefSeq - XM_006531484
RefSeq - XM_006531485
RefSeq - XM_006531486
RefSeq - XM_006531479
RefSeq - XM_006531480
RefSeq - XM_006531481
RefSeq - XM_006531482
RefSeq - XM_006531483
RefSeq Peptide - NP_083922
RefSeq Peptide - NP_001128572
swissprot - Q8R1R4
Ensembl - ENSMUSG00000031750
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il34ENSDARG00000091003Danio rerio
 IL34ENSGALG00000028466Gallus gallus
 IL34ENSG00000157368Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020415  Interleukin-34


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation ISO
 biological_processGO:0045657 positive regulation of monocyte differentiation ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005157 macrophage colony-stimulating factor receptor binding ISS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005398 decreased susceptibility to fungal infection "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014599 Csf1 / P07141 / Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1 / P09603* / colony stimulating factor 1*  / reaction / complex
 ENSMUSG00000024621 Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*  / complex / reaction
 ENSMUSG00000031750 Il34 / Q8R1R4 / Interleukin-34 / Q6ZMJ4*  / complex / reaction
 ENSMUSG00000020592 Sdc1 / P18828 / syndecan 1 / P18827*  / complex / reaction
 ENSMUSG00000068748 B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*  / reaction / complex






 

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